Study the Association between Erythropoietin Resistance and Polymorphisms in two genes, IL-1B and ACE in Egyptian Patients on Maintenance Hemodialysis
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 7
Abstract
The introduction of recombinant human erythropoietin (EPO) is effective treatment for anemia in chronic kidney disease patients The causes of inadequate response to EPO include iron deficiency, infection, chronic inflammation, and uremia. IL-1B-511C/T polymorphism has been associated with inflammation that plays important role in EPO resistance also the ACE gene polymorphism may display erythropoietic resistance. The study was conducted on 100 chronic kidney disease patients treated with hemodialysis. All participants gave informed consent .Clinical data were evaluated, including use of ACE inhibitors or angiotensin receptor blocker (ARB) prior to the time of the study. Lab investigations as Hb levels, serum albumin, total iron-binding capacity, high sensitivity C-reactive protein and Intact parathyroid hormone (PTH) levels.the aim of the study was to evaluate the association between( IL-1B-511C/T and ACE I/D gene polymorphisms) and EPO resistance index (ERI) We found that Patients with the ACE D/D genotype had lower ERI (6.4318± 3.43 IU/kg weight/g Hb) if compared with other two genotypes (ACE I/I, 8.248±2.35 IU/kg weight/g Hb; ACE I/D, 7.30±2.92 IU/kg weight/g Hb) also ERI Values were lower in IL-1B-511C/T individuals (6.64±2.43IU/kg weight/g Hb) than in IL-1B-511CC (7.27±3.03 IU/kg weight/g Hb) and IL-1B-511TT (8.50±3.32 IU/kg weight/g Hb) and this difference was significant .we concluded that ACE genotype has predictive value when determining the EPO dosage, as the II/ID genotypes may be associated with a suboptimal response to EPO. Also patients with IL-IB C/T may require less EPO than other two genotypes IL B T/T and IL B C/C
Authors and Affiliations
Heba ELshair
Keywords
Related Articles
- EP ID EP212121
- DOI -
- Views 88
- Downloads 0
Multi Organ Echinococcosis Including Liver, Lung, and Breast: A Rare Case Report
Hydatid disease (HD) is endemic in the many part of the world with more prominent regions are South America, New Zealand, Australia, Middle East Africa, Turkey and Southern Europe, but small foci are common in almost eve...
Knowledge, Attitude and Practices of Suturing and Management of Wound among Interns
Injuries in our body can cause the wound. Wound may differ by location and type. Sometime wound can be managed by the medicines and sometimes suturing also included. Suturing can be included in small wound to the emergen...
Needs to Define Physical Fitness Centres in India - An Analytical Study
Introduction: An increased awareness to promote physical fitness, especially gym goers was recorded globally. However due regulation and the needs of fitness industry including qualified trainers, due monitoring are logg...
Evaluation of Alvarado Scoring System in Preoperative Diagnosis of Acute Appendicitis
Background: Aim of the study was to evaluate Alvarado scoring system in preoperative diagnosis of Acute Appendicitis and to compare clinical diagnosis and Alvarado scoring for early diagnosis and correlate them with hist...
Prevalence of physical and genital injuries in female victim of rape: A Three Year Institution Based Cross-Sectional Study
Sexual violence is a significant cause of physical and psychological harm and suffering for women and children. Sexual violence constitutes the most barbaric crimes against the women. Sexual violence on female subject is...