Study the Association between Erythropoietin Resistance and Polymorphisms in two genes, IL-1B and ACE in Egyptian Patients on Maintenance Hemodialysis
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 7
Abstract
The introduction of recombinant human erythropoietin (EPO) is effective treatment for anemia in chronic kidney disease patients The causes of inadequate response to EPO include iron deficiency, infection, chronic inflammation, and uremia. IL-1B-511C/T polymorphism has been associated with inflammation that plays important role in EPO resistance also the ACE gene polymorphism may display erythropoietic resistance. The study was conducted on 100 chronic kidney disease patients treated with hemodialysis. All participants gave informed consent .Clinical data were evaluated, including use of ACE inhibitors or angiotensin receptor blocker (ARB) prior to the time of the study. Lab investigations as Hb levels, serum albumin, total iron-binding capacity, high sensitivity C-reactive protein and Intact parathyroid hormone (PTH) levels.the aim of the study was to evaluate the association between( IL-1B-511C/T and ACE I/D gene polymorphisms) and EPO resistance index (ERI) We found that Patients with the ACE D/D genotype had lower ERI (6.4318± 3.43 IU/kg weight/g Hb) if compared with other two genotypes (ACE I/I, 8.248±2.35 IU/kg weight/g Hb; ACE I/D, 7.30±2.92 IU/kg weight/g Hb) also ERI Values were lower in IL-1B-511C/T individuals (6.64±2.43IU/kg weight/g Hb) than in IL-1B-511CC (7.27±3.03 IU/kg weight/g Hb) and IL-1B-511TT (8.50±3.32 IU/kg weight/g Hb) and this difference was significant .we concluded that ACE genotype has predictive value when determining the EPO dosage, as the II/ID genotypes may be associated with a suboptimal response to EPO. Also patients with IL-IB C/T may require less EPO than other two genotypes IL B T/T and IL B C/C
Authors and Affiliations
Heba ELshair
Keywords
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