Study the association of midtrimester insulin resistance with development of pre-eclampsia among primi gravidae
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 21, Issue 1
Abstract
Objective: To determine the development of pre-eclampsia among primigravidae midtrimester pregnant women with insulin resistance. Method: 500 primigravidae normotensive women were included for the study on first come first basis and fasting insulin and fasting glucose was done on all of them. Insulin resistance was calculated by homeostasis model assessment of insulin resistance (HOMA-IR). Women having HOMA-IR 75 percentile were included in study group and women with HOMA-IR <75 percentile were included in control group. These women were followed up and again seen at time of delivery. Results: In our study we found that out of 376 control subjects (<75th percentile HOMA-IR), 351 (93.35%) were normotensive, 17 (4.52%) developed gestational hypertension and 8 (2.13%) subjects had preeclampsia at the time of delivery and in 124 cases (75th percentile HOMA-IR), 99 (79.84%) were normotensive, 11 (8.87%) developed gestational hypertension and in 14 (11.29%) cases we found to have preeclampsia at the time of delivery. Conclusion: Study results showed that raised mid trimester maternal insulin resistance is associated with a significant increase in risk of having preeclampsia later in pregnancy.
Authors and Affiliations
Lakshmi Salodia, Mohan Lal Meena, Bhamini Jakhetiya
Keywords
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