Study to evaluate the effectiveness of coagulation factor concentrate prophylaxis in children with severe hemophilia
Journal Title: Indian Journal of Child Health - Year 2017, Vol 4, Issue 1
Abstract
Objective: To evaluate the effectiveness of prophylaxis with coagulation factor concentrates VIII/IX (FVII/IX) in children with severe hemophilia A/B, respectively. Materials and Methods: Retrospective observational study was done on children enrolled in our hemophilia clinic, who initially received “on demand” therapy and were on prophylaxis with factor VIII/IX concentrate at the time of the study. The study group consisted of 8 children. Annual hemarthrosis rate (AHR) over a period of 1-year during on demand therapy was compared with AHR during a period of 1-year on prophylaxis with FVIII/IX. Results: There was reduction in AHR by 87% in hemophilia A and 85% in hemophilia B during prophylaxis compared to on demand therapy. There was a significant reduction in hemarthrosis/patient/year from 2.5 to 0.3 on prophylaxis with factor concentrate compared to on demand therapy. There was also reduction in other bleeding manifestation like psoas muscle bleed, oral bleeds, epistaxis, and number of target joints involved. Conclusion: Prophylaxis with coagulation factor concentrate significantly reduces the AHR, and hence, decreases the disability associated with it compared to “on demand” therapy.
Authors and Affiliations
S Udayakumar, K Pushpalatha, C Sushma, P M Swathi
Keywords
Related Articles
- EP ID EP454073
- DOI -
- Views 81
- Downloads 0
To evaluate the relation between central venous pressure and inferior vena cava collapsibility in cases of pediatric shock
Background: Invasive hemodynamic monitoring of central venous pressure (CVP) is a useful guide in directing early resuscitative efforts and assists in reducing the morbidity and mortality of the patients with septic shoc...
Opportunistic screening of at risk asymptomatic adolescent children for prediabetes
Background: Type 2 diabetes mellitus (T2DM) once considered an adult disease is now being reported in children and adolescents all over the world due to a parallel increase in obesity. Prediabetes is an intermediate stag...
Dengue hepatic severity score: A glimmer to the clinician
Introduction: Recent studies from India and Thailand show that dengue infection was the most compelling cause of acute hepatic failure in children contributing to 18.5% and 34.3%, respectively, and till now, there is no...
Perinatal testicular torsion - Not an uncommon entity
Perinatal testicular torsion is a rare condition with an incidence of 1 in 7500 live births. 70% are prenatal and 30% postnatal. Postnatal torsion presents as an acute scrotum, whereas prenatal torsion may be usually mis...
Mean platelet volume as a marker of Kawasaki disease in children
Background: Kawasaki disease (KD) is a clinical diagnosis, with common confusion among other causes of febrile illnesses. There are no confirmatory laboratory parameters for diagnosing KD. Objective: To investigate wheth...