STUDYING THE EFFECT OF DIFFERENT GELLING AGENT ON THE PREPARATION AND CHARACTERIZATION OF METRONIDAZOLE AS TOPICAL EMULGEL
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2019, Vol 12, Issue 3
Abstract
Objective: Emulgels as topical dosage form recently gains an interest represent a combination of gels and emulsions in united form. Metronidazole is an antimicrobial and anti-inflammatory drug, as the first topical therapy approved for rosacea; metronidazole has remained a cornerstone of rosacea management. Methods: Emulgel formulations of metronidazole benzoate were prepared using two types of gelling agents, Carbopol 940 and hydroxypropyl methylcellulose, the influence of type and concentration of them on the release of metronidazole benzoate was investigated. The prepared formulations were evaluated on the basis of pH, spreadability, viscosity, drug content, in vitro release, and compatibility studies. Results: All the prepared emulgels showed acceptable physical properties concerning color, homogeneity, consistency, spreadability, and pH value. Conclusion: The best formulation (F4) prepared using Carbopol 940 as gelling agent showed the highest drug release through 5 h.
Authors and Affiliations
NOOR M DAOOD, ZAINAB E JASSIM, MOWAFAQ M GAREEB, HIBA ZEKI
Keywords
Related Articles
- EP ID EP603929
- DOI -
- Views 166
- Downloads 0
PLACKETT-BURMAN DESIGN AS A TOOL FOR SCREENING AND PROCESS OPTIMIZATION OF RIVASTIGMINE-LOADED LIPID NANOCARRIERS
Objective: Plackett–Burman experimental design is used to identify the most important factors early in the experimentation phase when complete knowledge about the system is usually unavailable. The objective of this st...
PROTECTIVE ROLE OF PTEROSTILBENE ON PLASMA AND TISSUE GLYCOPROTEIN COMPONENTS IN HIGH-FAT DIET-FED AND STREPTOZOTOCIN-INDUCED TYPE 2 DIABETIC MICE
Objective: The aim of the current study is to evaluate the effect of pterostilbene (PTS), on deranged plasma and tissue glycoprotein components in high-fat-diet (HFD) and streptozotocin (STZ)-induced type 2 diabetic mice...
DEVELOPMENT OF FROVATRIPTAN SUCCINATE MICROEMULSION FOR NASAL DELIVERY: OPTIMIZATION, IN VITRO AND IN VIVO EVALUATION
Objective: The main objective of the present research work was to develop, optimize, and characterize microemulsion (ME) of frovatriptan succinate to improve brain transport. Methods: The pseudoternary phase diagrams we...
IN VITRO ANALYSIS OF ORNITHINE DECARBOXYLASE INHIBITORY ACTIVITY OF THE EXTRACTS OF EXCOECARIA AGALLOCHA L.
Objective: Ornithine decarboxylase (ODC) is one of the key enzymes involved in polyamine synthesis that has a prominent regulatory role in cell growth in prokaryotes and eukaryotes. Its regulation/inhibition is a potenti...
WET CHEMICAL SYNTHESIS, CHARACTERIZATION, AND ANTIBACTERIAL ACTIVITY OF MOLYBDENUM OXIDE NANOPARTICLES AGAINST STAPHYLOCOCCUS EPIDERMIDIS AND ENTEROBACTER AEROGENES
Objective: The objective of this study was to synthesize the molybdenum oxide nanoparticles (NPs) by employing wet chemical method and investigation of their antibacterial properties against pathogenic bacteria. Methods...