Sub-acute Effects of α-Fe2O3 Nanoparticles on Some Biochemical Parameters in Mice
Journal Title: Journal of Applied Veterinary Sciences - Year 2023, Vol 8, Issue 3
Abstract
The goal of the study was to find out the toxic effect of daily treatment with α-Fe2O3 nanoparticles for 14 and 28 days on some biochemical indicators in mice by measuring ferritin, transferrin, cholinesterase enzyme activity, the concentration of Caspase-3, and the concentration of glutathione and malondehyde in brain and liver tissues at doses of 75, 150 and 300 mg/kg. α-Fe2O3 nanoparticles at the dose of 75 mg/kg caused a significant decrease in the activity of the acetyl cholinesterase enzyme in the brain and liver after 14 days of treatment, compared with the control group and the doses of α- Fe2O3 (75, 150, and 300 mg/kg) led to a significant decrease in the activity of the acetyl cholinesterase enzyme in the brain after 28 days of treatment. Fe2O3 at a dose of 75 mg/kg on the 14th day and at a dose of 150 mg/kg on the 28th day of treatment resulted in a significant increase in the caspase-3 enzyme in the brain compared to the control group. While the doses of 150 and 300 mg/kg for 28 days led to a significant increase in transferrin concentration compared with the control group, The α-Fe2O3 nanoparticles at doses of 75, 150, and 300 mg/kg for 28 days caused a significant decrease in the concentration of glutathione in the liver and brain tissues compared with the control group, accompanied by a significant increase in the concentration of malondehyde in the brain and liver tissues at doses of 150 and 300 mg/kg of body weight. We conclude that repeated exposure to α - Fe2O3 nanoparticles has toxic effects on vital organs such as the brain and liver, represented by a decrease in the concentration of acetylcholinesterase and its ability to induce oxidative stress through a decrease in glutathione concentration and an increase in malondehyde concentration in mice .
Authors and Affiliations
Nashwan Adnan Al-hamadany and Muna Hazim Alzubaidy
Keywords
Related Articles
- EP ID EP718742
- DOI 10.21608/JAVS.2023.210749.1232
- Views 43
- Downloads 0
Incidence, Bacterial causes and Antibiotic Resistance Patterns of Urinary Tract Infection in Pet Animals
T The primary goal of the study was to determine the prevalence and various bacterial risks of lower urinary tract infections (UTI) in diseased and seemingly healthy pet animals with and without urine retention whether t...
Acetylcholine Esterase Gene Expression in Salivary Glands of Albino Rats after Treatment with amitriptyline or/and Ashwagandha
Acetylcholinesterase is required as an enzyme to counteract the effects of acetylcholine. The aim of the study is to assess how amitriptyline and Ashwagandha affect the acetylcholinesterase gene in rat salivary glands. F...
Histopathological And Ultrastructure Alterations In Gills Of Common Carp (Cyprinus Carpio) After Long Time Exposure To Zinc Oxide Nanoparticles
This study aimed to assess the toxicity and severity of zinc oxide nanoparticle (ZnO-NPs) in the tissues of gills. Therefore, carp fish (Cyprinus carpio) were subjected to sub-lethal concentration of (ZnO-NPs) 9mg/l for...
Bacteriological and Molecular Comparative Study between Staphylococcus aureus Isolated from Animals and Human
Staphylococcus aureus represents a serious health hazard on both animals and humans. The main goal of the present work was to compare between S. aureus isolated from animal and human origin. This was achieved through stu...
Using a Novel Nanoparticle as An Adjuvant for Inactivated Avian Influenza Vaccine
The present work evaluated the mesoporous silica nanoparticles (MSNs) as a promising adjuvant in preparation of inactivated avian influenza H9N2 vaccine in chicken. Two inactivated vaccine formulae were prepared by using...