Subcellular Localization of Geminin and Its Prognostic Effect in High-Grade Gliomas
Journal Title: Nepal Journal of Neuroscience - Year 2014, Vol 11, Issue 2
Abstract
Geminin is a nuclear protein and yet has been detected in cytoplasm as well. However, its subcellular localization on any human cancers has not yet become clear. This study investigated geminin subcellular localization and it effect on prognosis of high-grade gliomas (WHO Grade III and IV). Geminin subcellular localization in 52 cases of high-grade gliomas was determined by immunohistochemistry. The relation of geminin subcellular localization with clinical outcome in these malignant tumors was analyzed using Kaplan-Meier method and Cox proportional hazards regression model. Cytoplasmic geminin expression was signifi cantly associated with advancing tumor grade (one way analysis of variance (ANOVA), p=0.0240). The Kaplan- Meier curve showed that the patients with cytoplasmic geminin had a better prognosis (p=0.0230) than those without cytoplasmic geminin in Grade (Gr.) III glioma. The Cox regression test also showed that cytoplasmic geminin expression had a signifi cant relationship with survival in grade III patients (p=0.0192). However, the nuclear geminin didn’t show any such signifi cant correlation. Cytoplasmic geminin expression increases with advancing tumor grade. Subcellular geminin localization can be a signifi cant predictive factor for high-grade glioma prognosis, mainly in the early stage of malignant transformation.
Authors and Affiliations
Prabin Shrestha, MD, PhD
Keywords
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