Sublingual Misoprostol 400 Mcg Versus Intramuscular Oxytocin 10 Iu For Prevention Of Primary Post Partum Haemorrhage: An Open-Label Randomized Clinical Trial
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 10
Abstract
Introduction: Postpartum hemorrhage mostly due to uterine atony is responsible for about a third of maternal deaths. The present study is an attempt to compare the efficacy of i.v oxytocin and sublingual misoprostol for prevent of PPH. Our aims and objectives were to find out the efficacy of misoprostol for prevention of primary post partum haemorrhage in comparison with oxytocin and to find out its safety, side effects and acceptability. Materials and methods: The open label randomized clinical trial included total of 800 antenatal patients meeting the eligibility criteria .The patients were randomly assigned to receive either Oxytocin (10 U im ) or Misoprostol (400 mcg sublingual ) within 1 minute of delivery.If bleeding was >500 ml or placenta was not separated by 30 minutes , active management of PPH was done medical or surgical means as required.Patients were keenly monitored for 24 hours. Analysis of the data revealed that both groups were compared with respect to the basic demographic parameters. Results: Most of the patients in both did not have tachycardia and were normotensive although those in oxytocin group leaned more towards lower normal range .Pallor and icterus were equally prevalent in either groups.Incidence of retained placenta was 9 (2.25%) cases in misoprostol group and 6 (1.5%) in oxytocin group.(p=0.182). Incidence of PPH in misoprostol group was 7.5% and 5.25% in oxytocin group.The difference was not statistically significant.Severe PPH was noted in 4% patients in misoprostol group and 2.25% patients in oxytocin group (statistically not significant ;p= 0.329). Comparison of average blood loss in both groups showed 387±191.91 mL (misoprostol group) vs 386.03±149.23 mL (oxytocin group). The difference was not significant (p=0.937). Conclusion: Our study established that both misoprostol and oxytocin are equally effective in prevention of primary PPH due to uterine atony.
Authors and Affiliations
Dr Jhantu Kumar Saha, Dr Pallab Kumar Mistri, Dr Animesh Pal, Dr Sukumar Mitra
Keywords
Related Articles
- EP ID EP406728
- DOI 10.9790/0853-1710124044.
- Views 68
- Downloads 0
Foam Sclerotherapy-Alternative/Adjunct Treatment in Varicose Veins
Varicose veins is a growing menace in general population which commonly present with varicosities , pigmentation and relentless non healing ulceration. Ulcers range from small waxing and waning ulcers to circumferential...
Association of Squamous Cell Carcinoma of lower lip with Xeroderma Pigmentosa – A Devastating disease.
Xeroderma Pigmentosa is a rare inherited autosomal recessive disease characterised by inability to repair DNA damage caused by UV light. Those affected are extremely sensitive to the UV portion of the light. Affected ind...
Study of Pattern of Emerging Antifungal Resistance in A Zonal Hospital in North-East India.
Introduction: Superficial fungal infections of skin are common worldwide. The etiological agents are varied with emerging resistance pattern especially among azoles. The present study aims to demonstrate the current tren...
Study on Retinopathy And Microalbuminuria In Patients with Type 2 Diabetes Mellitus And Hypertension
Background: Retinopathy is a major cause of morbidity in India. Present study was undertaken to correlate retinopathy and microalbuminuria in patients with type 2 diabetes mellitus and hypertension. Methodology: 100 pati...
Congenital Cataract- Approach and Management Review
Childhood cataract remains a challenge to pediatric ophthalmologists despite recent major breakthrough in surgical techniques and instrumentation. Pediatric cataract is one of the major causes of preventable childhood bl...