Sublingual Misoprostol as an Adjunct to Oxytocin During Cesarean Delivery in Women at Risk of Postpartum Hemorrhage
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 2
Abstract
Objective: To assess the efficacy of sublingual misoprostol as an adjunct to parenteral oxytocin in preventing blood loss during and after surgery in patients with high risk for postpartum hemorrhage. Method: One hundred seventy-five women who were high risk for postpartum hemorrhage and undergoing emergency cesarean delivery were assigned randomly to receive either 400 μg misoprostol or placebo sublingually at the time of cord clamping. All participants received an intravenous infusion of 20 units of oxytocin. The primary outcome measures were intraoperative and postoperative blood loss. Results: Mean intraoperative blood loss was significantly less in misoprostol group as compared with placebo group (595 ± 108 vs. 651 ± 118 ml, P = 0.025). Perioperative Hb fall was significantly less in misoprostol group (0.87 ± 0.29 vs. 1.01 ± 0.26 g, P = 0.0018). Conclusion: Misoprostol as an adjunct to oxytocin is more efficient in preventing blood loss as compared to oxytocin alone.
Authors and Affiliations
Cimona Lyn Saldanha, Shabnum Araujo, Umrazia Bashir
Keywords
Related Articles
- EP ID EP544826
- DOI 10.21276/ijmrp.2017.3.2.067
- Views 82
- Downloads 0
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