Sublingual Misoprostol as an Adjunct to Oxytocin During Cesarean Delivery in Women at Risk of Postpartum Hemorrhage
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 2
Abstract
Objective: To assess the efficacy of sublingual misoprostol as an adjunct to parenteral oxytocin in preventing blood loss during and after surgery in patients with high risk for postpartum hemorrhage. Method: One hundred seventy-five women who were high risk for postpartum hemorrhage and undergoing emergency cesarean delivery were assigned randomly to receive either 400 μg misoprostol or placebo sublingually at the time of cord clamping. All participants received an intravenous infusion of 20 units of oxytocin. The primary outcome measures were intraoperative and postoperative blood loss. Results: Mean intraoperative blood loss was significantly less in misoprostol group as compared with placebo group (595 ± 108 vs. 651 ± 118 ml, P = 0.025). Perioperative Hb fall was significantly less in misoprostol group (0.87 ± 0.29 vs. 1.01 ± 0.26 g, P = 0.0018). Conclusion: Misoprostol as an adjunct to oxytocin is more efficient in preventing blood loss as compared to oxytocin alone.
Authors and Affiliations
Cimona Lyn Saldanha, Shabnum Araujo, Umrazia Bashir
Keywords
Related Articles
- EP ID EP544826
- DOI 10.21276/ijmrp.2017.3.2.067
- Views 65
- Downloads 0
Comparative Study of Young Male Smokers and Nonsmokers Regarding QTc Prolongation: A Hospital Based Study
Introduction: As per World Health Report (2002) tobacco is the most avoidable cause of overall as well as cardiovascular mortality worldwide. It was calculable that there have been a hundred million deaths worldwide in t...
Traumatic Sciatic Nerve Injury Following Intramuscular Injection: A Case Report
Traumatic sciatic nerve injury secondary to intramuscular (IM) injection is a common yet avoidable cause of nerve injury. Here we describe an 8-year-old boy who developed foot-drop secondary to IM injection. We will high...
Histopathological Spectrum of Renal Biopsy in Adult Onset Nephrotic Range Proteinuria: An Experience at a Tertiary Care Centre
Introduction: Adult onset nephrotic syndrome is broad clinical entity, needs further histological evaluation to reach a definite diagnosis. Hence, these patients should be investigated with renal biopsy. The aim of our s...
Diagnostic Efficacy of Pleural Fluid ADA, ICAM-1 and VCAM-1 to Differentiate Tubercular and Nontubercular Pleural Effusion
Background: Tuberculosis infection can occur in almost every organ in the body but involvement of lungs is most common. In extra pulmonary tuberculosis, tubercular pleural effusion is one of the commonest manifestations....
Making Norms of Peak Expiratory Flow Rate in Adolescent: A Cross Sectional Study At Bhopal
Background: Peak expiratory flow rate (PEFR) recording is an essential measure in the management and evaluation of asthmatic subjects. Objective: The present study was undertaken to establish normal reference values for...