[sub][/sub]Role of Granulocyte Colony Stimulating Factor (G-Csf) in Neonatal Sepsis with Neutropenia
Journal Title: People's Journal of Scientific Research. - Year 2016, Vol 9, Issue 2
Abstract
Randomized controlled double blind trial was done at NICU, Department of Pediatrics, MLB Medical College, Jhansi to determine whether adjunctive therapy with G-CSF could reverse sepsis associated neonatal neutropenia and improve neonatal survival compared with conventional therapy. 52 neonates with sepsis and absolute neutrophil count(ANC)<1800/mm3. The G-CSF group (n=26) received G-CSF single daily dose of 10 mg/kg/day subcutaneously for 3 days along with conventional therapy while control group (n=26) received conventional therapy (antibiotic and supportive care) alone. Hematological parameters [ANC, total leukocyte count (TLC)] on day 0,1,3,7 & 14 of study entry, neonatal survival and duration of hospital stay were compared between two groups. Basic demographic profile among two groups were comparable. By day 3, ANC among G-CSF group was significantly higher 8292±605.21 compared to control group 1544.04±250.49(p value <0.0001). Mortality rate was significantly lower in G-CSF group than in control group 11.53% vs 46.15%. Duration of hospital stay in G-CSF group was 18.32±4.42 compared to 24.57±9.06 in control group( p value 0.0027). G-CSF can increase the neutrophil count, decrease mortality rate and reduce duration of hospital stay in critically ill septic neutropenic neonates. Further studies are required to confirm our results and establish the adjunctive therapy in neonatal sepsis
Authors and Affiliations
Priyanka Gupta, , RS Sethi,, Om Chaurasia, , Anuj Sethi,
Keywords
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