Successful Rapid Desensitization of Two Teenagers with Rituximab Hypersensitivity
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 5
Abstract
ABSTRACT Rituximab is one of the monoclonal antibodies that is used in the management of malignancies and auto-inflammatory disorders. Rituximab causes Hypersensitivity Reactions (HSRs) during infusions. The delay of treatment or loss of a highly efficient drug can be prevented by rapid drug desensitization method in patients who are allergic to rituximab. Although HSRs and desensitization protocols to mAbs have been well described in adults, the experience in the paediatric population is very limited. To best of author’s knowledge, this is the first case series describing a novel, rapid desensitization protocol against rituximab hypersensitivity in two teenagers with high-grade B cell non-Hodgkin’s lymphoma and steroid-resistant minimal change disease who developed hypersensitivity to rituximab. Here, authors present case reports of two patients who were desensitized successfully by using novel rapid desensitization protocol for rituximab.
Authors and Affiliations
Murat Cansever, Alper Ozcan, Ismail Dursun, Ekrem Unal, Fulya Tahan
Keywords
Related Articles
- EP ID EP583376
- DOI 10.7860/JCDR/2019/38080.12821
- Views 119
- Downloads 0
Role of Diffusion Weighted Imaging in Differentiating Benign from Pathological Vertebral Collapse using ADC Values
ABSTRACT Introduction: Vertebral fractures are very commonly encountered in day to day practice. Diffusion Weighted Imaging (DWI) with Apparent Diffusion Coefficent (ADC) values is a novel technique to evaluate vertebral...
Importance of Mycologic Evaluation in Chronic Non Healing Ulcers
ABSTRACT Chronic non healing ulcers are caused by various aetiologies ranging from infections, autoimmune disorders to neoplasms. Fungal infections are important yet neglected cause of non healing ulcers. In most of the...
Diabetes and Diabetic Retinopathy: Knowledge, Attitude, Practice (Kap) among Diabetic Patients in A Tertiary Eye Care Centre
Introduction: Diabetic retinopathy is becoming an increasingly important cause of visual impairment in India. Many diabetic patients who come to our centre have undetected, advanced diabetic retinopathy. If diabetic reti...
Effect of Socio-Economic Factors on Reproductive Health in Female Heads of Household: A Cross-Sectional Study in Iran
ABSTRACT Introduction: Attention to reproductive health and its related factors is an essential step towards the promotion of health in societies and families with an emphasis on role of women. Considering the increase i...
Chondroid Syringoma: Fine-needle Aspiration Cytology of a Rare Entity at an Unusual Site
Chondroid syringoma, also known as benign mixed tumour of the skin, is a rare benign adnexal tumour. It is a biphasic tumour, composed of both epithelial and mesenchymal components and constitutes <0.01% of all primary s...