Suppressed Fluctuation In The Gabaergic Signaling: Mathematical Modeling Of The Neurotransmitter
Journal Title: International Journal of Fundamental Physical Sciences - Year 2015, Vol 5, Issue 4
Abstract
The chemistry of the gamma-aminobutyric acid (GABA) had been established. However, the explanation on the interplay between GABA receptors antagonizes fundamental concept of the GABAergic Signaling. For example, glutamate spillover from excitatory afferent terminals leads to the modulation of GABAergic signals. However, this result is true with respect to GABAB receptors only. The physics of its interplay between the GABA receptors was theoretically investigated using the magnetic resonance imaging (MRI) because the proton gradient controls the intermediate energy storage for heat production and flagellar rotation. The MRI investigation of the GABAergic Signaling is not a new concept in medicine. The molecular potential in the receptors increases the peak radiofrequency (RF) field (B1) amplitude and the holding potential of the GABA receptors. The suppressed fluctuation of the GABAergic Signaling was noticed where the receptors are all actively involved in the GABAergic network. Hence, a dual technique was suggested to detect the suppressed GABAergic state in the human body.
Authors and Affiliations
Moses E. Emetere, Bijan Nikouravan, M Agarana
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