Suppression of Inflammatory Mediators by the Ethanol Extract of Crotalaria verrucosa L. leaf – in vivo and in vitro Analysis
Journal Title: European Journal of Medicinal Plants - Year 2016, Vol 11, Issue 3
Abstract
Objective: The present study demonstrated the potential of Crotalaria verrucosa L., a widely used medicinal plant of Bangladesh, ethanolic leaf extract in inhibiting the cascades of inflammation. Methods: Carrageenan induced rat paw edema and xylene induced mice ear edema tests were performed as in vivo assessment of anti-inflammatory activity. Moreover, these methods were supported by the in vitro heat induced protein denaturation and haemolysis tests. Results: In all experiments CVE extract shows moderate to significant efficacy. CVE 600 mg/kg significantly suppressed the biological response (edema) in comparison to both steroidal and non-steroidal anti-inflammatory drugs. Moreover in vitro study suggested that the leaf extract at doses of 300, 400 and 500 µg/ml possess moderate to high inhibition capacity for auto antigen production which exerts extract’s potential against Type III hypersensitivity. Conclusion: All these data support the safe use of this plant traditionally. However, the extract is yet to be explored for responsible compounds and specific mechanisms.
Authors and Affiliations
Kashfia Nawrin, Mohammad Mustakim Billah, Mohammed Sahek Ullah Jabed, Md. Main Uddin, Md. Nurul Islam
Keywords
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- EP ID EP349557
- DOI 10.9734/EJMP/2016/21894
- Views 89
- Downloads 0
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