Suppression of Inflammatory Mediators by the Ethanol Extract of Crotalaria verrucosa L. leaf – in vivo and in vitro Analysis
Journal Title: European Journal of Medicinal Plants - Year 2016, Vol 11, Issue 3
Abstract
Objective: The present study demonstrated the potential of Crotalaria verrucosa L., a widely used medicinal plant of Bangladesh, ethanolic leaf extract in inhibiting the cascades of inflammation. Methods: Carrageenan induced rat paw edema and xylene induced mice ear edema tests were performed as in vivo assessment of anti-inflammatory activity. Moreover, these methods were supported by the in vitro heat induced protein denaturation and haemolysis tests. Results: In all experiments CVE extract shows moderate to significant efficacy. CVE 600 mg/kg significantly suppressed the biological response (edema) in comparison to both steroidal and non-steroidal anti-inflammatory drugs. Moreover in vitro study suggested that the leaf extract at doses of 300, 400 and 500 µg/ml possess moderate to high inhibition capacity for auto antigen production which exerts extract’s potential against Type III hypersensitivity. Conclusion: All these data support the safe use of this plant traditionally. However, the extract is yet to be explored for responsible compounds and specific mechanisms.
Authors and Affiliations
Kashfia Nawrin, Mohammad Mustakim Billah, Mohammed Sahek Ullah Jabed, Md. Main Uddin, Md. Nurul Islam
Keywords
Related Articles
- EP ID EP349557
- DOI 10.9734/EJMP/2016/21894
- Views 108
- Downloads 0
Evaluation of Haemolytic Activity of Leaves from Acacia podalyriifolia
Acacia podalyriifolia A. Cunn ex G. Don (Fabaceae) is a plant used in south Brazil for ornamental purposes. The leaves are used in folk medicine for the treatment of bacterial infection, diabetes, gastrointestinal distur...
Anti-ulcerogenic Activity of Aqueous Extract of Unripe Fruit of Musa sapientum Linn in Combination with Vitamin C on Ulcer Induced Models in Experimental Rats
Aims: To evaluate the effect of aqueous extract of unripe fruit of Musa sapientum Linn in combination with Vitamin C on aspirin and ethanol induced ulcer models in Wistar rats. Study Design: Anti-ulcer study. Place and...
Evaluation of Ex-vivo Anti-arthritic, Anti-inflammatory, Anti-cancerous and Thrombolytic Activities of Mussaenda roxburghii Leaf
Aim: The current study evaluates the anti-arthritic, anti-inflammatory, anti-cancerous and thrombolytic activities of methanolic extract of Mussaenda roxburghii leaf. Place and Duration of study: This study was conducted...
Cytotoxicity of the Aqueous Extract of Clerodendrum splendens on HaCaT Keratinocytes
Clerodendrum splendens G. Don (Family Verbenaceae) has been used for centuries to treat various medicinal problems in Africa, including the treatment of wounds and other skin conditions. Though several studies have been...
Effects of Chemical and Biological Fertilizers on Morpho-Physiological Traits of Marigold (Calendula officinalis L.)
Aims: Fertilizer management is an important factor for a successful growth of officinal plants and the identity of suitable fertilizers in plants could have the desirable effects on quantitative and qualitative indices....