[sup][/sup] Evidences of hepatoprotective and antioxidant effect of Citrullus colocynthis fruits in paracetamol induced hepatotoxicity

Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 3

Abstract

 The objective of present study was to explore the hepatoprotective and antioxidant profile of Citrullus colocynthis fruits. Hepatoprotective profile of methanolic extract of Citrullus colocynthis fruits (MECCF) was investigated on rats, which were made hepatotoxic using paracetamol. The antioxidant profile of MECCF was evaluated by conducting Catalase, Super oxide Dismutase, Lipid Peroxidation and Diphenyl Picryl Hydrazyl tests. During hepatoprotective investigation, the Paracetamol treated group II showed significant increase in total bilirubin (TB), serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT) and alkaline phosphatase (ALP) level. The results so obtained showed that pretreatment of rats with MECCF 300mg/kg p.o. decreases the elevated TB, SGOT, SGPT and ALP serum levels. Also, MECCF inhibitory profile was found comparable with toxicant group (Paracetamol 2g/kg, p.o.). The present study concludes that MECCF fruit possess significant hepatoprotective and antioxidant activity.

Authors and Affiliations

Syed Vakiloddin , Neeraj Fuloria , Shivkanya Fuloria , Sokkalingam Arumugam Dhanaraj , Kaveti Balaji , Sundram Karupiah

Keywords

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  • EP ID EP100488
  • DOI -
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How To Cite

Syed Vakiloddin, Neeraj Fuloria, Shivkanya Fuloria, Sokkalingam Arumugam Dhanaraj, Kaveti Balaji, Sundram Karupiah (2015). [sup][/sup] Evidences of hepatoprotective and antioxidant effect of Citrullus colocynthis fruits in paracetamol induced hepatotoxicity. Pakistan Journal of Pharmaceutical Sciences, 28(3), 951-957. https://europub.co.uk/articles/-A-100488