Surface Acidity and Solid-State Compatibility of Excipients with an Acid-Sensitive API: Case Study of Atorvastatin Calcium
Journal Title: AAPS PharmSciTech - Year 2015, Vol 16, Issue 2
Abstract
The online version of this article (doi:10.1208/s12249-014-0231-7) contains supplementary material, which is available to authorized users.
Authors and Affiliations
Ramprakash Govindarajan, Margaret Landis, Bruno Hancock, Larry A. Gatlin, Raj Suryanarayanan, Evgenyi Y. Shalaev
Keywords
Related Articles
- EP ID EP682206
- DOI 10.1208/s12249-014-0231-7
- Views 60
- Downloads 0
Particle Margination and Its Implications on Intravenous Anticancer Drug Delivery
“Margination” refers to the movement of particles in flow toward the walls of a channel. The term was first coined in physiology for describing the behavior of white blood cells (WBCs) and platelets in bl...
Hydrogels Composed of Cyclodextrin Inclusion Complexes with PLGA-PEG-PLGA Triblock Copolymers as Drug Delivery Systems
Although conventional pharmaceuticals have many drug dosage forms on the market, the development of new therapeutic molecules and the low efficacy of instant release formulations for the treatment of some chronic disease...
Development of Novel Docetaxel Phospholipid Nanoparticles for Intravenous Administration: Quality by Design Approach
The objective of this study was to develop novel docetaxel phospholipid nanoparticles (NDPNs) for intravenous administration. Modified solvent diffusion-evaporation method was adopted in the NDPN preparation. Central com...
Development of Modified-Release Tablets of Zolpidem Tartrate by Biphasic Quick/Slow Delivery System
Zolpidem tartrate is a non-benzodiazepine analogue of imidazopyridine of sedative and hypnotic category. It has a short half-life with usual dosage regimen being 5 mg, two times a day, or 10 mg, once daily. The duration...
Finite Element Method (FEM) Modeling of Freeze-drying: Monitoring Pharmaceutical Product Robustness During Lyophilization
Lyophilization is an approach commonly undertaken to formulate drugs that are unstable to be commercialized as ready to use (RTU) solutions. One of the important aspects of commercializing a lyophilized product is to tra...