Surface Acidity and Solid-State Compatibility of Excipients with an Acid-Sensitive API: Case Study of Atorvastatin Calcium

Journal Title: AAPS PharmSciTech - Year 2015, Vol 16, Issue 2

Abstract

The online version of this article (doi:10.1208/s12249-014-0231-7) contains supplementary material, which is available to authorized users.

Authors and Affiliations

Ramprakash Govindarajan, Margaret Landis, Bruno Hancock, Larry A. Gatlin, Raj Suryanarayanan, Evgenyi Y. Shalaev

Keywords

Related Articles

Impact of Physicochemical Environment on the Super Disintegrant Functionality of Cross-Linked Carboxymethyl Sodium Starch: Insight on Formulation Precautions

The aim of this work is to improve the understanding of the physicochemical mechanisms involved in the functionality of cross-linked carboxymethyl sodium starch (CCSS) as a tablet super disintegrant (SD). The behavior an...

Multifunctional Nanoparticles for Prostate Cancer Therapy

The relapse of cancer after first line therapy with anticancer agents is a common occurrence. This recurrence is believed to be due to the presence of a subpopulation of cells called cancer stem cells in the tumor. There...

Assessment of Active Pharmaceutical Ingredient Particle Size in Tablets by Raman Chemical Imaging Validated using Polystyrene Microsphere Size Standards

Particle size is a critical parameter for controlling pharmaceutical quality. The aim of this study was to assess the size of the micrometer-scale active pharmaceutical ingredients (API) in tablets using Raman chemical i...

An Investigation on the Effect of Polyethylene Oxide Concentration and Particle Size in Modulating Theophylline Release from Tablet Matrices

Polyethylene oxide has been researched extensively as an alternative polymer to hydroxypropyl methylcellulose (HPMC) in controlled drug delivery due to its desirable swelling properties and its availability in a number o...

Nanoemulsions in Translational Research—Opportunities and Challenges in Targeted Cancer Therapy

Nanoemulsion dosage form serves as a vehicle for the delivery of active pharmaceutical ingredients and has attracted great attention in drug delivery and pharmacotherapy. In particular, nanoemulsions act as an excellent...

Download PDF file
  • EP ID EP682206
  • DOI  10.1208/s12249-014-0231-7
  • Views 78
  • Downloads 0

How To Cite

Ramprakash Govindarajan, Margaret Landis, Bruno Hancock, Larry A. Gatlin, Raj Suryanarayanan, Evgenyi Y. Shalaev (2015). Surface Acidity and Solid-State Compatibility of Excipients with an Acid-Sensitive API: Case Study of Atorvastatin Calcium. AAPS PharmSciTech, 16(2), -. https://europub.co.uk/articles/-A-682206