SURGICAL BIOCOMPOSITES WITH CHITOSAN
Journal Title: Progress on Chemistry and Application of Chitin and its Derivatives - Year 2009, Vol 0, Issue
Abstract
Reported are investigations in the formulation and preparation method of hydroxyapatite composites in form of glue, sponge and shaped products. Osteosynthesis ability, mechanical properties susceptiblity to biodegradation and biocompatibility of the prepared materials were assessed. It was found that, based on chitosan and hydroxyapatite, a material can be prepared with good gluing properties. Crucial is the useful form of chitosan and its physicalchemical properties like pH, polymer content and viscosity. 3 days from the application of the glue are required to complete osteosynthesiss both for porous and smooth bones which, a time acceptable in surgery for the fusion of bones. The glue joints in form of a film undergo enzymatic degradation in the presence of lysozyme. After 28 days action of the enzyme at a concentration of 200 mg/ cm3, the mass loss of the glue was about. 21%. From the compressed chitosan hydrroxyapatite sponge, elastic shaped products can be prepared presenting the potential use as defect fillers in maxillofacial surgery.
Authors and Affiliations
Antoni Niekraszewicz, Magdalena Kucharska, Maria Wiśniewska-Wrona, Danuta Ciechańska, Krzysztof Haberko
Keywords
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