Surgical management of ulcerative colitis: A descriptive mini review

Journal Title: Journal of Indira Gandhi Institute of Medical Sciences - Year 2016, Vol 2, Issue 2

Abstract

Ulcerative colitis is a colonic mucosal inflammatory pathology characterized by bloody diarrhea. The disease usually starts in colon and gradually extends upwards to involve various extent of colon.The clinical course varies from case to case with a characteristic periods of exacerbation and remission.In India it is more prevalent than it’s counterpart crohn’s disease and commonly differs from it with respect to etiology ,clinical,endoscopy and histopathology. It usually is seen to start in 2nd and 6th decade of life with no striking prepondorence to any sex. The exact etiology is not known. But factors strongly and positively associated are the family history, environment and recurrent infections. Appendectomy, breast feeding and smoking can be protective in selected patients. Pathology seems to occur because of a disturbance of balance between the gut immunity and the intestinal flora. This leads to an immunological reaction mediated by the dendritic cells and macrophages in the mucosa further leading to breach in mucosal barrier and infiltration with inflammatory cells from the blood. There is mucous depletion, crypt problems, erosions and ulceration which in late stages may lead to loss of haustration with a pipe like deformity.

Authors and Affiliations

Nihar Ranjan Das, Hemant Jain

Keywords

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  • EP ID EP288860
  • DOI -
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How To Cite

Nihar Ranjan Das, Hemant Jain (2016). Surgical management of ulcerative colitis: A descriptive mini review. Journal of Indira Gandhi Institute of Medical Sciences, 2(2), 8-15. https://europub.co.uk/articles/-A-288860