Survival and prognostic indicators in hepatitis b surface antigen: Positive cirrhosis of the liver
Journal Title: International Journal of Medical and Health Research - Year 2018, Vol 4, Issue 7
Abstract
To assess signs for modern treatments such as liver transplantation and antiviral treatment, survival of histologically demonstrated hepatitis B surface antigen (HBsAg)-positive cirrhosis of the liver was evaluated in a cohort of 98 patients taken after up for a cruel of 4.3 a long time. The by and large survival likelihood was 92% at 1 year, 79% at 3 a long time, and 71% at 5 a long time. Factors essentially related with the term of survival were age, serum aspartate aminotransferase levels, nearness of esophageal varices, and all five components of the Child-Pugh file (bilirubin, egg whites, coagulation components, ascites, and encephalopathy). Multivariate examination appeared that as it were age, bilirubin, and ascites were autonomously related to survival. Survival of patients with decompensated cirrhosis (decided by the nearness of ascites, jaundice, encephalopathy, and/or a history of variceal dying) and those with compensated cirrhosis at 5 a long time was 14% and 84%, separately. For patients with compensated liver cirrhosis, hepatitis B e antigen (HBeAg) inspiration was moreover a prognostic figure with a 5-year survival of 72% for HBeAg-positive cirrhosis and 97% for HBeAg-negative cirrhosis; the chance of passing was diminished by a calculate of 2.2 when HBeAg seroconversion happened amid follow-up. It is concluded that liver transplantation ought to be considered for patients with decompensated HBsAg-positive liver cirrhosis and antiviral treatment for patients with HBeAg-positive compensated cirrhosis.
Authors and Affiliations
Manar Ahmed, Tariq Alshami, Abdullah Alghamdi, Anas Algethmi, Asalah Saeedi, Ameer Mesawa
Keywords
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