SURVIVIN EXPRESSION IN COLORECTAL ADENOCARCINOMAS
Journal Title: IJSR-International Journal Of Scientific Research - Year 2017, Vol 6, Issue 9
Abstract
Introduction : Colorectal adenocarcinomas contribute to a significant proportion of cancer related morbidity and mortality. Survivin is a novel member of the IAP family of proteins involved in apoptosis inhibition, being overexpressed in many cancers. This study was done to evaluate the expression of Survivin in colorectal adenomas and adenocarcinomas and its association with the clinicopathological tumor characteristics. Materials and methods : Immunohistochemical analysis of Survivin expression was performed on 30 cases each of normal colorectal mucosa, adenomas and adenocarcinomas respectively. Results: Survivin expression was absent in normal mucosa with increased expression in adenomas and maximal expression in adenocarcinomas. It also correlated with the degree of differentiation of adenocarcinomas. Conclusion : The results indicate that dysregulation and over expression of Survivin is involved in colorectal tumorigenesis and malignant transformation of adenomas.
Authors and Affiliations
Dr. S. Brihadisvarar, Dr. Nalli. R. Sumitra Devi
Keywords
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