Sustained Release Multiple Unit Dosage Form for the Oral Day Delivery of Dexketoprofen Trometamol
Journal Title: Open Access Journal of Pharmaceutical Research - Year 2017, Vol 1, Issue 3
Abstract
The aim of this study was to prepare sustained release multiple unit dosage form (MUDF) for the oral day delivery of the frequently administered and the highly water soluble drug, dexketoprofen trometamol (DT). The drug was encapsulated into Eudragit RS100 microspheres using emulsification solvent evaporation technique. A D-optimal design was used to determine the effect of amount of polymer (X1), the percentage of hydrophobic plasticizer (X2), the percentage of hydrophilic plasticizer (X3), and stirring rate (X4), on the % entrapment efficiency (Y1), amount of drug released at 1h (Y2), 4h (Y3), and 8 h (Y4). The optimized formulation was prepared using 1.39 g Eudragit, 0.063 g Dibutyl phthalate (DBP), 0.093 g Polyethylene Glycol 400 (PEG 400) and processed using stirring rate of 683 rpm. The optimized microspheres were evaluated by Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), and Xray Diffraction (XRD). Results of the optimized formula showed that the microspheres were spherical with a rough surface and a particle size of 32±1.41 µm, with entrapment efficiency 76.0±1.76%. The amount of drug released was 33.7±0.82%, 60.2±0.05%, and 75.1±1.84%, at 1, 4, and 8 h, respectively. Complete drug release was achieved after 16 h. The sustained release pattern of DT for up to 16 h with an acceptable initial release suggests that the developed MUDF may be useful for oral day delivery of the highly soluble and frequently administered drug such as DT.
Authors and Affiliations
Sweed NM, Basalious EB and Nour SA*
Keywords
Related Articles
- EP ID EP745763
- DOI 10.23880/oajpr-16000114
- Views 1
- Downloads 0
Chikungunya Emerging Health Crises in Pakistan: Are we Going in the Right Direction
The unstable health care system of Pakistan saw a major setback in the form of dengue outbreak in 2011. Despite massive governmental efforts, with each passing year dengue continues to cause significant morbidity and mo...
Phytochemical Analysis of Traditional Medicinal Plants and their Antimicrobial Activity: An Experience from North East India
Introduction: Phytochemicals are non-nutritive, chemical compounds that occur naturally on plants and have diverse protective properties .Most Phytochemicals like carotenoids, flavonoids and polyphenols have antimicrobia...
Diclofenac Sodium Loaded Nanosized Ethosomes: An Investigation on Z-Average, Polydispersity and Stability
Diclofenac sodium is a non-steroidal anti-inflammatory drug (NSAID). Oral therapy with NSAID is always associated with several side effects such as gastric bleeding, and ulceration. The purpose of this work was to explor...
Medication Errors
These results relied on data voluntary provided to American Hospital Association. It is likely that substantial number of medication errors go undetected or unreported to the hospital medication error reporting system.
Antihyperlipidemic and Antibacterial Activities of Baccaurea Courtallensis Leaves
The present study evaluated the antihyperlipidemic and antibacterial activities of B. courtallensis extract. The antihyperlipidemic effect of B. courtallensis methanol extract was studied in Triton WR-1339 and high fat d...