Synergistic Antibacterial and Antifungal Activities of Spondiasmombin(Linn) Extracts and Conventional Antibiotic and Antifungal Agents on Selected Clinical Microorganisms
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2017, Vol 5, Issue 2
Abstract
Abstract: Spondiasmombin is a plant widely used in folkloric medicine. It has lots of potential as a medicinal plant. Most of these potentials are yet to be discovered and its anti-infective property could be maximized either by using it alone or combining it with other plants and conventional antibiotics as a means of combating the problem of antibiotic resistance. The aim of the present work is to investigate the synergistic antimicrobial activity of various concentration of extracts of Spondiasmombin and ofloxacin investigate the synergistic antifungal activity of extract of Spondiasmombin and fluconazole, compare the antimicrobial and antifungal activity of the various parts of the plant (leaf, bark and stem) and to compare the activity of the aqueous and crude ethyl acetate extracts of Spondiasmombim and 30 organisms were used for the research. They include 10 (ten) typed bacterial, 10 (ten) locally isolated bacteria and 10 (ten) locally fungal isolates and the results obtained revealed a higher zone of inhibition against the pathogens tested. The findings from this work suggest that Spondiasmombin contain some compounds that can enhance the effect of conventional antibiotics and antifungal agents in inhibiting the growth of pathogens. Keywords:Spondiasmombin, conventional antibiotics
Authors and Affiliations
Osuntokun OludareTemitope, Ogunmodede A. F, O. A Fasusi, A. O Thonda, A. E Odufuwa
Keywords
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