SYNERGISTIC EFFECT OF GALANTAMINE CARRIED ON A NOVEL NANO-DRUG DELIVERY SYSTEM ON INDUCED LUNG DISORDERS IN ALZHEIMER’S DISEASE
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2017, Vol 6, Issue 8
Abstract
Alzheimer's disease AD, the most common form of dementia, usually presents with lung disorders including lung fibrosis. The aim of the present study was to verify that the curative role of Galantamine (the major therapeutic drug for AD) coated with Ce/Ca-HAp (nano-drug delivery particle) on brain tissue is capable of inducing similar therapeutic capabilities in lung disorders besides its role in AD therapy. Presentation of multiple biomarkers (CYP1A1, CYP2E1, TGF- β1, TAC and TOC) for pulmonary disorders and also brain Markers (5-OH tryptamine, TNF-α & IL-ß1) measured in brain tissuemay induce early detection thus adding to the efficacy of the curative competence. 64 adult female albino Wistar rats (189- 200 gm) were allotted into 4 groups: a) Control: Gonad intact rats (10). b) Alzheimer (Alz): Ovariectomized rats (22) treated orally with AlCl3 (17 mg/kg b.wt) daily for 2 months following one month surgery. c) Alz + Gal rats (16) d) Alz + Gal. + Ce/Ca-HAp rats (16). Results verified marked increases in levels of TNF-α & IL-ß1, TOC, TGF-ß1 while serum TAC and 5-OH tryptamine levels and tissue CYP1A1, CYP2E1 were significantly decreased in AD rats. Histologically, thickening wall of blood vessels and lymphocytes inflammatory infiltration and degenerative alterations were viewed in lung tissue. Patent enhancements were more asserted following nano-therapy than GAL alone. In conclusion, as lung dysfunction highly presents with AD thus early detection using different biomarkers as lung profile (CYP1A1, CYP2E1, TGF-β1) antioxidant and oxidative status (TAC, TOC) and brain markers profile (5-OH tryptamine, TNF-α & IL-ß1) is vital for curative competence. Again as Ce/Ca-HAp nanoparticle presented as coating for GAL drug therapy, more promising ameliorative measures could be achieved.
Authors and Affiliations
Dr. Walaa Ahmed Moustafa El-Nahrawy
Keywords
Related Articles
- EP ID EP618385
- DOI -
- Views 113
- Downloads 0
ADVANTAGES AND DISADVANTAGES OF MODERN GLASS CARBOMER CEMENTS
Glass carbomer cements are modern dental materials, which are used more often in the dental practice, in the treatment of tooth decay or for fixing of different prosthetic constructions. Objective: The aim of this resear...
CONTRACT MANUFACTURING & MERCHANT EXPORTERS THE BUILDING BLOCKS OF INDIAN PHARMACEUTICAL EXPORTS.
India has been a major contributor to fulfill the pharmaceutical demand of the world. With world class generics and cutting edge technology for biologics and vaccines Indian manufacturers have been capable enough to meet...
ANALGESIC ACTIVITY OF ASPHODELUS MICROCARPUS LEAVES EXTRACT
Our study aims to investigate the existence of the analgesic activity on methanolic extract from leaves of Asphodelus microcarpus(A.m.). It's parts in the context valuation the traditional pharmacopoeia. The peripheral a...
A CRITICAL REVIEW ON STANDARDIZATION OF BHASMA: AYURVEDIC AND MODERN VIEW
Ayurvedic medicines are serving the needs of ailing humanity since many centuries. Particularly Bhasmas have good preventive, curative and rejuvenating potential. Bhasma are the unique Ayurvedic metallic, non-metallic or...
CRITICAL REVIEW OF ANUKTA DRAVYA “LAHSUN BEL (MANSOA ALLIACEA)
Medicinal plants are scientifically documented in Ayurvedic literature based on the sound fundamentals of rasa (Taste), guna (Property), virya (Potency), vipaka (Metabolism) and prabhava (Specific action).Vedic to Samhit...