Synergistic interaction between acetaminophen and carbamazepine in mice
Journal Title: Medicamentul Veterinar / Veterinary Drug - Year 2014, Vol 8, Issue 1
Abstract
This study aims to demonstrate the type of pharmacodynamic interaction and the demonstration of an antinociceptive action of fixed-ratio binary combinations between a non-opioid analgesic (acetaminophen) and an anticonvulsant (carbamazepine) as a rational way to treat pain. All experimental procedures used in this study were closely in line with international bioethical regulations on experiments conducted on laboratory animals. For quantifying the interaction, we used the method of the additive composite curve, which allows the quantitative assessment of the pharmacodynamic interactions of binary combinations in fixed proportion. The interaction between these substances is the synergistic (potentiation), as evidenced by the left shift of the regression curve of the combination compared to the composite additive curve. The statistical parameters of regression analysis reveal the synergism between the two substances (Zmix = 39.276 ± 7.54 mg / kg ( Zmix < Zadd ) the interaction index Ȗ = 0.387 , p < 0.05, tc = 3.753 , tt = 3.511 Fc = 10.825 , Ft = 4.260 ). The synergism between the two substances is explained by the specific action mechanisms of each substance
Authors and Affiliations
Lidia Chitac, Sorin Beschea, Monica Neamtu, Delia Bulea, Veronica Bild
Keywords
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