Synergistic Interactions Between Anticancer Chemotherapeutics and Phenolic Compounds and Anticancer Synergy Between Polyphenols

Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue

Abstract

Chemoprevention has recently gained a new dimension due to the possibility of studying the mechanisms of action of chemopreventive agents at the molecular level. Many compounds have been proved to inhibit early stages of carcinogenesis in experimental models. These compounds include both recognized drugs (such as tamoxifen and nonsteroidal anti-inflammatory drugs) and natural constituents of edible and therapeutic plants, particularly polyphenols. Phenolics are characterized by high structural diversity and, consequently, a very broad spectrum of biological activities. They are increasingly looked upon as a valuable alternative or a support for synthetic drugs, as evidenced by a growing number of clinical trials regarding the use of phenolic compounds and polyphenol-rich extracts in chemoprevention and therapy. In the present work, we discuss the effectiveness of natural polyphenols as cancer preventive and therapeutic agents resulting from their synergy with synthetic or semisynthetic anticancer drugs as well as with other phenolic compounds of plant origin.

Authors and Affiliations

Urszula Lewandowska, Sylwia Gorlach, Katarzyna Owczarek, Elżbieta Hrabec, Karolina Szewczyk

Keywords

Related Articles

Pleiotropic action of proinsulin C-peptid

Proinsulin C-peptide, released in equimolar amounts with insulin by pancreatic β cells, since its discovery in 1967 has been thought to be devoid of biological functions apart from correct insulin processing and forma...

Oxidative stress in prostate hypertrophy and carcinogenesis

Aging, significant impairment of the oxidation/reduction balance, infection, and inflammation are recognized risk factors of benign hyperplasia and prostate cancer. Chronic symptomatic and asymptomatic prostate inflammat...

Rothia mucilaginosa, rarely isolated pathogen as an etiological factor of infection of soft tissues in young, healthy woman

This paper presents a rare case of facial soft tissue infection caused by the bacterial strain of Rothia mucilaginosa. Odontogenic background of infection and initial clinical presentation suggested the presence of typic...

Stres oksydacyjny i naturalne mechanizmy antyoksydacyjne – znaczenie w procesie neurodegeneracji. Od mechanizmów molekularnych do strategii terapeutycznych

Wiele obserwacji wskazuje, że procesem leżącym u podłoża neurodegeneracji jest stres oksydacyjny. Neurony są bardziej niż inne komórki narażone na uszkodzenie oksydacyjne, ze względu na bardziej intensywny metabolizm tle...

System CRISPR-Cas – od odporności bakterii do inżynierii genomowej

Precyzyjne modyfikacje genomów wprowadzane z dużą wydajnością są istotne do zrozumienia, jaki wpływ na procesy biologiczne i stany chorobowe mają konkretne geny lub inne elementy genomu. W ostatnich latach pojawiły się n...

Download PDF file
  • EP ID EP67366
  • DOI -
  • Views 162
  • Downloads 0

How To Cite

Urszula Lewandowska, Sylwia Gorlach, Katarzyna Owczarek, Elżbieta Hrabec, Karolina Szewczyk (2014). Synergistic Interactions Between Anticancer Chemotherapeutics and Phenolic Compounds and Anticancer Synergy Between Polyphenols. Advances in Hygiene and Experimental Medicine, 68(), 528-540. https://europub.co.uk/articles/-A-67366