Synergistic Interactions Between Anticancer Chemotherapeutics and Phenolic Compounds and Anticancer Synergy Between Polyphenols
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
Chemoprevention has recently gained a new dimension due to the possibility of studying the mechanisms of action of chemopreventive agents at the molecular level. Many compounds have been proved to inhibit early stages of carcinogenesis in experimental models. These compounds include both recognized drugs (such as tamoxifen and nonsteroidal anti-inflammatory drugs) and natural constituents of edible and therapeutic plants, particularly polyphenols. Phenolics are characterized by high structural diversity and, consequently, a very broad spectrum of biological activities. They are increasingly looked upon as a valuable alternative or a support for synthetic drugs, as evidenced by a growing number of clinical trials regarding the use of phenolic compounds and polyphenol-rich extracts in chemoprevention and therapy. In the present work, we discuss the effectiveness of natural polyphenols as cancer preventive and therapeutic agents resulting from their synergy with synthetic or semisynthetic anticancer drugs as well as with other phenolic compounds of plant origin.
Authors and Affiliations
Urszula Lewandowska, Sylwia Gorlach, Katarzyna Owczarek, Elżbieta Hrabec, Karolina Szewczyk
Keywords
Related Articles
- EP ID EP67366
- DOI -
- Views 151
- Downloads 0
The participation of outer membrane proteins in the bacterial sensitivity to nanosilver
The presented study is to analyze the participation of outer membrane proteins of Gram- negative bacteria in sensitivity to silver nanomaterials. The mechanism of interaction of silver with the bacterial cell is best des...
Częstość stosowania leczenia biologicznego na Dolnym Śląsku u chorych z reumatoidalnym zapaleniem stawów i zesztywniającym zapaleniem stawów kręgosłupa
MMP-9 directed shRNAs as relevant inhibitors of matrix metalloproteinase 9 activity and signaling
Introduction: The main function of matrix metalloproteinases is the degradation of extracellular matrix components, which is related to changes in the proliferation of cells, their differentiation, motility, and death. M...
Mitogen-activated protein kinases in atherosclerosis
Intracellular signalling cascades, in which MAPK (mitogen-activated protein kinases) intermediate, are responsible for a biological response of a cell to an external stimulus. MAP kinases, which include ERK1/2 (extracell...
Programowana śmierć komórek – strategia utrzymania komórkowej homeostazy organizmu
Programowana śmierć komórki (PCD) jest procesem, w którym dzięki zdolności komórek do samobójczej śmierci, mogą być eliminowane komórki zbędne i uszkodzone, co pozwala na utrzymanie fizjologicznej homeostazy organizmów w...