Synteza i aktywność biologiczna pochodnych 2,6-naftyrydyny
Journal Title: Wiadomości Chemiczne - Year 2012, Vol 66, Issue 3
Abstract
2,6-Naphthyridine is one of the six structural isomers of pyridopyridines. This review presents most of the literature data about natural and synthetic 2,6-naphthyridine derivatives and their biological activity. The main goal of this paper is to present various methods for the preparation of 2,6-naphthyridine analogues. Compounds containing 2,6-naphthyridine moiety can be synthesized from different substrates. Most of them have been obtained by cyclocondensation of various pyridine derivatives. During the past twenty years the biological activity of 2,6-naphthyridines have been studied. Presented compounds exhibit anticancer [21, 41], antihypertension [10], and antidepression [25] activity. Some of them can be used in the treatment of heart diseases [22], appetite disturbance, and obsessive states [43, 44]. 2,6-Naphthyridine derivatives with different molecular targets, e.g. topoisomerase [41], SERT [27], and protein kinases [21, 22] inhibitors have also been reported. Many of the 2,6-naphthyridine analogues are histamine H3 [27] and serotonine 5-HT2 [42–44] receptor antagonists.
Authors and Affiliations
Anna Wójcicka, Edwin Wagner
Keywords
Related Articles
- EP ID EP590141
- DOI -
- Views 130
- Downloads 0
2,2'- Dihydroksy-1,1'-binaftyl (BINOL ) i jego pochodne. Wybrane syntezy i zastosowanie. Część I
1,1’-Binaphthyl and its derivatives represent a particular class of chemical molecules which chirality results from the restricted rotation about single bond of the two naphthalene rings. This generates the chirality axi...
Hiperwalentne związki siarki, selenu i telluru. Część 2. Sulfurany 10-S-3 i 10-S-4
The compounds presented herein are sulfuranes 10-S-3 and 10-S-4 containing hypervalent sulfur atom. They have been known for a relatively long time. Nevertheless, they, and especially 10-S-4 species, are still of great i...
Błękit Majów , jedno z najważniejszych osiągnięć Mezoameryki
The Maya Blue is a famous blue pigment developed by pre-Columbian civilizations of Mesoamerica and manufactured there for about thousand years. It was applied for body decoration, important for cruel religious rituals, a...
Transport przeznaskórkowy aktywnych składników kosmetycznych
This article presents the science output regarding percutaneous transport mechanisms, penetration promotors and the methods of active substances skin absorption enhancement. The interaction between cosmetic ingredient an...
Wzór Scherrera : stulecie błędnych praktyk
We present the sources of uncertainty in the evaluation of grain size in nanomaterial. The calculations are made for the same diffraction pattern using Scherrer and Williamson-Hall methods. As an example we use the CoCr2...