Synteza i badania oddziaływania z albuminą N,N-pdimetyloaminobenzylowej pochodnej tiosemikarbazonu i jej kompleksu z rutenem(II)
Journal Title: CHEMIK nauka-technika-rynek - Year 2013, Vol 67, Issue 2
Abstract
Z literatury wiadomo, że niektóre tiosemikarbazony wykazują działanie antynowotworowe jako inhibitory reduktazy rybonukleotydowej, a ich koordynacja do jonów Ru może prowadzić do wzmocnienia tej reaktywności. W artykule przedstawiono syntezę tiosemikarbazonu N,N-p-dimetyloaminobenzaldehydu oraz jego kompleksu z Ru(II). Zbadano oddziaływanie otrzymanych związków z albuminą przy użyciu metod spektrofluorymetrycznych. Wykazano, że po związaniu w kompleks ligand jest mniej reaktywny w stosunku do albuminy, co rokuje nadzieje na jego lepszą biodystrybucję.
Authors and Affiliations
Michał Łomzik, Małgorzata Brindell
Keywords
Related Articles
- EP ID EP135612
- DOI -
- Views 66
- Downloads 0
Evaluation of properties of biomass used for energy purposes
Biomass is a technologically difficult fuel due to its physical and chemical properties, significantly different from coal combusted in power plant boilers. At the Institute for Chemical Processing of Coal research, conc...
Application of the life cycle assessment (LCA) metod for assessing the impact of mechanically loaded mining blasting materials on the environment
The environmental life cycle assessment (LCA) is a method that allows assessing the impact of production processes and the usage of mining explosives on the environment, which is still relatively new in Poland. LCA is an...
Spectrophotometric determination of UV protection provided by cosmetic products with sunscreen properties
The UV protection provided by sunscreens is an issue of raising importance due to the constantly increasing knowledge about the negative effects that UV radiation induces in the human skin. A number of recent studies hav...
Applying of spectroscopic methods in the investigation of radical polymerization processes and products
The utilization of spectroscopic methods in polymer chemistry allows obtaining the necessary information to identify the chemical structure of compounds and moreover different processes studies, starting from initiator s...
Physicochemical properties of fertilizers available on market and possibility of production of blended fertilizers
The paper discusses the methods and the results of research of physical and chemical compatibility of selected fertilizer mixtures and the evaluation of their possibility for production of blended fertilizers.