Syntezy, struktury i aktywność biologiczna pochodnych imidazo[4,5-b] pirydyny. Część II
Journal Title: Wiadomości Chemiczne - Year 2013, Vol 67, Issue 3
Abstract
The main goal of this article is to present selected syntheses, structures and a various biological activity of imidazo[4,5-b]pyridine derivatives. During the past 20 years the biological activity of imidazo[4,5-b]pyridine have been intensively studied. Based on the review of the chemical literature, it was shown that derivatives of imidazole[4,5-b]pyridine showed a multipharmacological effects such as antibacterial effect [20–22] and antituberculotic activity [25–33], nonsteroidal antiinflammatory activity [35–43] and analgesic [44, 45] effect. Among compounds of this class antagonists of angiotensin II receptors that exhibit hypotensive activity are also known [9–11]. Compounds containing imidazo[4,5-b]pyridine moiety can be synthesized from different substrates. The most useful starting compounds for the synthesis of imidazo[4,5-b]pyridine are derivatives of 2,3-diaminopyridine [1–3].
Authors and Affiliations
Hanna Liszkiewicz, Anna Nowicka, Wanda Paulina Nawrocka
Keywords
Related Articles
- EP ID EP585313
- DOI -
- Views 124
- Downloads 0
Biomateriały stosowane w inżynierii komórkowej i medycynie regeneracyjnej
Tissue engineering is a very rapidly developing domain of science. There is a huge interest in the biology of stem cells, especially in their proliferation, differentiation and spreading in the response to different fact...
Zastosowanie soli chinoliniowych i pirydyniowych do oznaczania wybranych związków siarki w próbkach biologicznych
heterocyclic ring [4, 13, 23]. In analytical chemistry quinolinium and pyridinium salts such as 2-chloro-1-methylquinolinium tetrafluoroborate (CMQT) or 1-benzyl-2-chloropyridinium bromide (BCPB) perform very well as thi...
Kwasy nukleinowe jako katalizatory reakcji chemicznych
Nucleic acids, due to their specific structure, are effective and durable carriers of genetic information. They have also been used as catalysts in chemical reactions. The right-handed DNA double helix structure has beco...
Reakcje asymetrycznego otwierania pierścienia azyrydyn
Aziridines, the nitrogenous analogues of epoxides, are useful building blocks for the synthesis of various functional materials and biologically active compounds. The reactivity of aziridines toward ring opening and expa...
W poszukiwaniu układu okresowego dla materii w skali nano
The purpose of this article was a presentation of the state of the art in the search of the periodic system for matter in nanoscale. It was preceded by a history of the discovery of traditional periodic table of the elem...