Syntheses, Characterization and In-Vitro Anti-Inflammatory Activity of Some Novel Thiophenes
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2012, Vol 5, Issue 2
Abstract
Aim: The present study was aimed to synthesize a series of 2-substituted benzylidine imino-3-(3- chloro-4-fluorophenyl)-carboxamido-4,5-trimethylene thiophenes SPJ-1(a-m) and to evaluate their in-vitro anti-inflammatory activity. Materials and Methods: The starting material (SPJ-1) was prepared by the application of versatile Gewald reaction. The In-vitro anti-inflammatory activity of synthesized compounds [SPJ-1(a-m)] was evaluated using inhibition of bovine serum albumin denaturation method. Result: SPJ-1b and SPJ-1g have shown significant in-vitro anti-inflammatory activity. Conclusion: The findings of the present study clearly demonstrate that chloro functional group possess inhibition of bovine serum albumin denaturation capacity and has in-vitro anti-inflammatory activity. However hydroxyl, nitro, methyl, methoxy and dimethyl amino derivatives did not show any in-vitro anti-inflammatory activity.
Authors and Affiliations
Satyendra Deka| Assam Down Town University, Dept. of Pharmacy, Panikhati, Guwahati-26, Assam, India, Shamanna Mohan| Department of Pharmaceutical Chemistry, P.E.S. College of Pharmacy, Bangalore-50, Karnataka, India, Janardhan Saravanan| Department of Pharmaceutical Chemistry, P.E.S. College of Pharmacy, Bangalore-50, Karnataka, India, Manoj Kakati| Department of Pharmaceutical Chemistry, P.E.S. College of Pharmacy, Bangalore-50, Karnataka, India, Apurba Talukdar| Assam Down Town University, Dept. of Pharmacy, Panikhati, Guwahati-26, Assam, India, Bhargab Jyoti Sahariah| Assam Down Town University, Dept. of Pharmacy, Panikhati, Guwahati-26, Assam, India, Biplab Kumar Dey| Assam Down Town University, Dept. of Pharmacy, Panikhati, Guwahati-26, Assam, India, Rama Kanta Sarma| Govt. Ayurvedic College, Dept. of RS & VK Guwahati-14, Assam, India
Keywords
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- EP ID EP8859
- DOI 10.3889/MJMS.1857-5773.2012.0225
- Views 280
- Downloads 16
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