SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SCHIFF BASE DERIVATIVES OF 4-CHLORO-3-NITROBENZOIC ACID
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 12
Abstract
4-chloro-3-nitrobenzoic acid was selected as nucleus structure having good antibacterial property. It was thought worthwhile to synthesize Schiff base derivatives of 4-chloro-3-nitrobenzoic acid in search of better antibacterial agents. The compounds were synthesized by first reducing nitro group in presence of Sn/HCl to 3-amino-4-chlorobenzoic acid, which on treatment with substituted benzaldehyde afforded the synthesis of the envisaged compounds. The synthesized compounds were purified and chemically characterized. They were screened for their antibacterial activity and result suggested that SKY-1, SKY-5 and SKY-8 were highly active against both Gram (+) and Gram(-) bacteria like B.subtilis, S.aureus and E.coli whereas all are were found moderately to inactive against P.aeruginosa.
Authors and Affiliations
Santosh Kumari , Dharmchand Singh
Keywords
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