Abstract

A series of 5-acetyl-2,3-diarylthiazolidin-4-one were synthesized from Schiff base 1 of substituted benzaldehyde and substituted aniline which on treatment with thioglycolic in presence of zinc chloride undergo cyclization to give 2,3-diarylthiazolidin-4-one 2. Which on further reaction with acetyl chloride in presence anhydrous sodium acetate furnished the title compounds 3. These compounds were characterized by IR, 1H NMR spectral data. The synthesized compounds were evaluated for their in vivo anticonvulsant activity using maximal electroshock seizure (MES) model in mice. Standard drug Phenytoin was administered intraperitoneally at a dose of 25 mg/kg. The test compounds were active at a dose of 30 mg/kg. The abolition of hind limb tonic extensor phase was recorded as measures of anticonvulsant activity and failure to extend limb to an angle greater than 90̊ is defined as protection. Out of tested compounds 3j was the most active compound of the series.

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