Synthesis And Antidepressant Activity Of TetraHydro Benzothiophene Derivatives

Apply

Synthesis And Antidepressant Activity Of TetraHydro Benzothiophene Derivatives

Journal Title: VIMS Health Science Journal - Year 2018, Vol 5, Issue 1

Abstract

The synthesis, structure and biological activity of benzothiophene has been long focus of research interests in the field of Medicinal Chemistry. Benzothiophene nucleus has been established as the potential entity in the largely growing chemical world of heterocyclic compounds possessing promising pharmacological characteristics. A series of tetrahydro benzothiophene derivatives was synthesized with an objective to develop novel and potent antimicrobial agents of synthetic origin. The required starting material 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate was synthesized via a multicomponent condensation between sulphur, cyclohexanone and ethylcyanoacetate adopting Gewald Reaction.The Compound 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylate was Reacted into respective substituted chloroacetanilide. The synthesized compound were further processed into the final compounds i.e.2-{[Substituted-phenylcarbamoyl)-methyl]-amino}-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carboxylic acid ethyl ester. All synthesized compound were characterized by IR, H1-NMR and elemental Analysis. All the newly synthesized derivatives were screened for Antidepressant activity using Sertraline HCL as a standard.

Authors and Affiliations

Dr. P Y Pawar, K A Mohalkar

Keywords

Tetrahydro-benzothiophenes Antidepressant.

The antiepileptic effect of Riluzole & in Combination with Phenytoin on Maximal Electroshock Induced Seizures in Albino Rats: An Experimetnal study

Despite the introduction of several new therapeutic options, a significant fraction of the patients with epilepsy continue to live with uncontrolled seizures. Although large no. of antiepileptic drugs are available in...

To study the effect of Pretreatment with Lidocaine and Diclofenac in Reducing Succinylcholine induced Myalgia

Assessment of psychosomatic symptyoms of menstruation Among Adolecent Girl Studying In Selected Educational Institutes of Pune

Liver enzymes in patients with chronic kidney diseases undergoing hemodialysis

To Study The Polymorphic Chromosomal Variants And Male Infertility

Objectives: To find out the frequency and types of polymorphic chromosomal variants and its impact in male infertility. Design: A case control study was carried on peripheral blood lymphocytes with standard G-banding tec...

EP ID EP623610
DOI -
Views 51
Downloads 0