SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF 5-{4'-[(4"-ARYL)- -3"-CYANO 2"-METHOXY PYRIDINE-6"-YL] PHENYL CARBAMIDO}-DIBENZ [b,f] AZEPINES
Journal Title: Int J of Pharm Res & Analy - Year 2015, Vol 5, Issue 2
Abstract
The titled compounds (4a-4k) have been synthesized by the condensation of 5-{4'-[(3"-aryl)-2"-Propene-1"-one]- Phenyl carbamido}-dibenz [b,f] azepines with malononitrile and Sodium methoxide. The biological activities of these compounds have been determined against various Gram +ve, Gram –ve bacteria and fungi. The constitutions of the products are supported by IR, 1 H NMR, Mass spectra and elemental analysis
Authors and Affiliations
Ramesh K. Kanpariya , Vithal N. Patolia
ANTIOXIDANT DEFENSE ENZYMES ACTIVITY IN HYPOBARIC HYPOXIA SUSCEPTIBLE AND TOLERANT SPRAGUE DAWLEY RATS
Antioxidant enzymes are known defense molecules, which eliminate reactive oxygen species (ROS) and free radicals that damage useful enzymes in the cell under various stress conditions. Significant efforts have been made...
SPECTROPHOTOMETRIC METHOD FOR DETERMINATION OF Fe(II) AND Zn(II) IN MULTIVITAMIN SOFT GEL CAPSULE
The present work describes novel spectrophotometric method for the determination of Fe(II) and Zn(II) in multivitamin soft gel formulation. The method is based on formation of coloured complexes of Fe(II) and Zn(II...
MICROSPONGES: A NOVEL DRUG DELIVERY SYSTEM FOR CONTROLLED DELIVERY OF TOPICAL DRUGS
Even though possess several advantages topical formulations have some drawbacks such as the need to contain high concentrations of active agents for effective therapy due to the low efficiency of delivery system, r...
RAPID SEPARATION AND ESTIMATION OF LAMIVUDINE AND ZIDOVUDINE IN MARKETED FORMULATIONS USING RP-HPLC METHOD AND ITS VALIDATION
The goal of the present investigation was carried out to develop a validated analytical RP-HPLC method for simultaneous separation and estimation of Lamivudine and Zidovudine for pharmaceutical formulations. The chromat...
ANALYTICAL TECHNIQUES FOR THE ESTIMATION OFAGOMELATINE IN BULK AND PHARMACEUTICAL DOSAGE FORMS: A REVIEW
Agomelatine (N-[2-(7-methoxynaphthalen-1-yl) ethyl] acetamide), its antidepressant efficacy has been verified in the treatment of major depressive disorder (MDD).Agomelatine showed significant benefits over paroxetine du...