SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 2-NAPHTHYLACETATE MANNICH BASES
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 6
Abstract
Using 2-naphthylacetate as active hydrogen component, the following Mannich bases were synthesized via a general synthesis protocol: 1-hydroxymethyl-1-piperidinomethyl-2-naphthylacetate(I); 1,1-dimorpholinomethyl-2- Naphthylacetate(II) and 1,1-bis-dimethylaminomethyl-2-naphthylacetate(III).The structures of the final products was elucidated by a combination of spectral techniques (UV,IR , 1HNMR and MS). The target molecules were evaluated for antimicrobial activity against six standard human pathogens. Significant activity was exhibited by compound I. It showed antimicrobial activity against all test organisms. Compounds II and III showed significant antifungal activity,
Authors and Affiliations
Prof. Abdel Karim M.
Keywords
Related Articles
- EP ID EP649163
- DOI -
- Views 138
- Downloads 0
CHRONIC AMEBIASIS [ENTAMOEBA HISTOLYTICA]: DETECTION BY IMMUNODIAGNOSIS METHOD
Enzyme immunoassay (EIA) kits for Entamoeba histolytica antibody detection are commercially available. Antibody detection is most useful in patients with extra intestinal disease (amebic liver abscess) when organisms are...
PRELIMINARY ASSESSMENT OF BATS AT PADER CAVE, VICTORIA, ZAMBOANGA CITY, WESTERN MINDANAO, PHILIPPINES
The study was conducted to gather information on bats in Pader Cave, Victoria, Zamboanga City. Specifically, the study aimed to identify species of bats, species dominance, and occurrence of species per station and docum...
TYPE II DIABETES MELLITUS AND DIASTOLIC DYSFUNCTION; 100 CASES
Objective; Frequency of diastolic dysfunction in patients having type II DM Methodology; This was a cross sectional study that was conducted at Medical department of Sheikh Zayed Hospital, Rahim Yar Khan during May to Oc...
EVALUATION OF ANTIOXIDANT ACTIVITY OF THE PLANT TEUCRIUM CAPITATUM L AND SILENE VULGARIS
For the evaluation of the antioxidant activity of the extracts of Silene vulgaris and Teucrium capitatum L and of the essential oils of the latter two tests were carried out: The DPPH (2, 2-diphenyl-1-picrylhydrazyl) tes...
POLYMORPHISM OF SIMVASTATIN: AN EFFORT TO REPAIR SOLUBILITY AND DISSOLUTION RATE
Objective: Simvastatin (SV) is most commonly used as a hypercholesterolemia drug, although it is poorly soluble in water and poorly absorbed by the gastrointestinal tract and has a bioavailability approaching 5%. This st...