SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 2-NAPHTHYLACETATE MANNICH BASES
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 6
Abstract
Using 2-naphthylacetate as active hydrogen component, the following Mannich bases were synthesized via a general synthesis protocol: 1-hydroxymethyl-1-piperidinomethyl-2-naphthylacetate(I); 1,1-dimorpholinomethyl-2- Naphthylacetate(II) and 1,1-bis-dimethylaminomethyl-2-naphthylacetate(III).The structures of the final products was elucidated by a combination of spectral techniques (UV,IR , 1HNMR and MS). The target molecules were evaluated for antimicrobial activity against six standard human pathogens. Significant activity was exhibited by compound I. It showed antimicrobial activity against all test organisms. Compounds II and III showed significant antifungal activity,
Authors and Affiliations
Prof. Abdel Karim M.
Keywords
Related Articles
- EP ID EP649163
- DOI -
- Views 144
- Downloads 0
CONCEPT OF OLIGOGALACTIA AND ITS MANAGEMENT IN UNANI SYSTEM OF MEDICINE – A REVIEW
Breast-feeding may be considered an ancient yet modern phenomenon. Despite trends toward bottle feeding in the 1950s and 1960s, the value of breast feeding is being rediscovered, because it is nutritionally ideal and now...
ESTIMATION OF BACTERIAL LOAD IN GINGIVA OF PATIENTS WEARING REMOVABLE DENTURES ATTENDING OUT PATIENT CLINICS FOR REVIEW
Dentures are inevitable part of modern dentistry. India has approximately about 7.7% of partial and completely edentulous population.[1] This population size is estimated to increase rapidly by the year 2030.[2] Factors...
FORMULATION AND EVALUATION OF EUDRAGIT RL 100 AND EUDRAGIT RS100 LOADED SESQUITERPENOIDS NANOPARTICLES
Objective: β-Caryophyllene (BCP) is a natural sesquiterpene existing in the essential oil of many plants, has exhibited a wide range of biological activities. However, its volatility and poor water-solubility limit its a...
ROLE OF IMPAIRED SLEEP ON DIABETES MELLITUS
Background: Over the past 30 years there has been an increase in the prevalence of insomnia and diabetes, both of which have serious consequences for longevity and quality of life. Because of this, various serious diseas...
e-MEDICINE PROVIDES 24 HOURS WEEKLY NONSTOP SERVICE TO THE BEST OF MANKIND
e-medicine is serving to the human by following 24 hours weekly without any fail for best and prompt medical help. Just as the printing press democratized information, the medicalized smartphone will democratize health c...