SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF TRIAZINOINDOLES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Several new 3,4-dihydro-4-oxo-1,2,4-triazino(4,5-a) indoles (3a-g) were synthesized string from ethyl substituted indole-2-carboxylates (1a-g) which were allowed to react with hydrazine hydrate (80%) in ethanol to furnish the corresponding indole-2-Carboxy hydrazine (2a-g) all the synthesized compounds were screened for their antimicrobial activity. In continuation of our studies on the synthesis of bihetrocyclic compounds containing indole nucleus we report the synthesis of new triazinoindoles these bihetrocyclic were tested for their antimicrobial activity. The reaction sequence leading to the formation of 2-3 is outlined in the Scheme-1 Substituted indole -2-carboboxylate (1a-g) were treated with hydrazine hydrate to get the respective indole -7-Carboxy-hydrazides (2a-g) these hydrazides when reacted with ethyl orthoformate in DME good yielded 3,4-dihydro-4-oxo-1,24-triazino94,5-a) indoles (3a-g)
Authors and Affiliations
Parwati C. V , Ramesh H. , Prakash Patil , sonar V. N , Neelavati C. V
Keywords
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