SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF TRIAZINOINDOLES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 3
Abstract
Several new 3,4-dihydro-4-oxo-1,2,4-triazino(4,5-a) indoles (3a-g) were synthesized string from ethyl substituted indole-2-carboxylates (1a-g) which were allowed to react with hydrazine hydrate (80%) in ethanol to furnish the corresponding indole-2-Carboxy hydrazine (2a-g) all the synthesized compounds were screened for their antimicrobial activity. In continuation of our studies on the synthesis of bihetrocyclic compounds containing indole nucleus we report the synthesis of new triazinoindoles these bihetrocyclic were tested for their antimicrobial activity. The reaction sequence leading to the formation of 2-3 is outlined in the Scheme-1 Substituted indole -2-carboboxylate (1a-g) were treated with hydrazine hydrate to get the respective indole -7-Carboxy-hydrazides (2a-g) these hydrazides when reacted with ethyl orthoformate in DME good yielded 3,4-dihydro-4-oxo-1,24-triazino94,5-a) indoles (3a-g)
Authors and Affiliations
Parwati C. V , Ramesh H. , Prakash Patil , sonar V. N , Neelavati C. V
Keywords
Related Articles
- EP ID EP124725
- DOI -
- Views 104
- Downloads 0
DAPAGLIFLOZIN: NEWER MOLECULE FOR TREATMENT OF TYPE 2 DIABETES MELLITUS
Type 2 diabetes mellitus is a common chronic disease that causes significant morbidity and mortality worldwide. Diabetes results from a combination of increased hepatic glucose production, decreased insulin secretion fro...
IN VITRO CYTOTOXIC EFFECT OF METHANOLIC CRUDE EXTRACTS OF TERMINALIA CHEBULA
The aim of this work is to observe invitro cytotoxic effect of methanolic crude extracts of Terminalia chebula (Family: Combretaceae). The bark of Terminalia chebula were soaked with methanol and then methanolic crude ex...
SOLID LIPID NANOPARTICLES: A PROMISING DRUG DELIVERY SYSTEM
Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, research and clinical medicine, as well as in other varied sciences....
CUMIN (CUMINUM CYMINUM L.; UMBELLIFERAE) CULTIVATION IN WEST BENGAL PLAINS, KALYANI, NADIA
Cumin (Cuminum cyminum L.; Family: Umbelliferae) is a seed spice of commercial importance as well as it is a potential medicinal herb with immense therapeutic uses not withstanding its significance in health food formula...
STUDY ON EXTRACTS OF PARMELIA PERLATA ACH. FOR ITS ANTIMICROBIAL POTENTIAL AGAINST CERTAIN MICROORGANISMS
A significant increase in the trend of infectious diseases and alarming shoot up of resistance to existing antimicrobial agents demands a renewed effort to seek agents effective against pathogenic bacteria resistant to c...