Synthesis and Antimicrobial evaluation of Azole Based (p-nitro Benzoic Acid) derivatives
Journal Title: Asian Pacific Journal of Health Sciences - Year 2018, Vol 5, Issue 4
Abstract
This study includes the Synthesis of Azoles Based p-nitro Benzoic Acid Derivative. The compounds were prepared by reaction of p-nitro Benzoic Acid with thiosemicarbazide in the presence of Phosphorus oxychloride to yield 1, 3, 4-thiadiazole nucleus. Further this thiadiazole was treated with different aromatic aldehydes in presence of methanol to yield corresponding Schiff’s bases. All the Schiff’s bases thus obtained were reacted with Thioglycolic acid to yield the title compounds. Synthesized derivatives were characterized by IR, H1NMR and screened for their antibacterial (S. aureus, B. subtilis, E. coli, and P. aerugiosa) and antifungal activity (A. Niger and C. albicans).
Authors and Affiliations
Omprakash Sharma
Keywords
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- EP ID EP517973
- DOI 10.21276/apjhs.2018.5.4.10
- Views 200
- Downloads 0
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