Synthesis and Assessment of Anti-inflammatory Activity of a Chlorosubstituted Chalcone Derivatives and using the Semi-empirical Methods to Measure the Linked Physicochemical Parameters
Journal Title: Journal of Pharmaceutical and Biomedical Sciences - Year 2016, Vol 6, Issue 11
Abstract
The present research was planned to synthesize chlorinated chalcone derivatives by condensing acetophenone with chlorinated benzaldehyde in presence of sodium hydroxide. The anti-inflammatory activity was evaluated practically by measuring cotton bellets induced granuloma. Theoretical evaluation was made by using HyperChem software. Chlorinated chalcone derivatives (CHD) showed comparable anti-inflammatory effect to diclofenac sodium, and less than dexamethsone.
Authors and Affiliations
Mazin Nadhim Mousa
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