Synthesis and biological activity of new derivatives of 6-chloro-5-((4-chlorophenyl) diazenyl) pyrimidine-2, 4-diamine and 4-chloro-6-methoxy-N, N-dimethylpyrimidin-2-amine
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 1
Abstract
6-chloro-5-((4-chlorophenyl) diazenyl) pyrimidine-2, 4-diamine and 4-chloro-6-methoxy-N,N-dimethylpyrimidin-2-amine has been used as precursors for the synthesis of new pyrimidine derivatives, employing Suzuki cross-coupling reaction. Thus, treatment of pyrimidine derivative with various arylboronic acids in the presence of palladium tetraacetate, PhP3 and Na2CO3 in refluxing n-propanol afforded the target compounds. The synthesis was supported by spectroanalytical techniques. The synthesized compounds have been screened for their inhibitory activity against some microbial, the results were showed that among gram positive isolates only (1/10) isolates of S. aureus and (3/10) isolates of S. saprophyticaus were sensitive for compound 13, while (1/10) isolates of S. aureus and (1/10) isolates of S.saprophyticaus were sensitive for compound 4. All isolates of S. pyogenes were resisting to all compounds, among gram negative bacterial isolates only (2/10) isolates of E. coli and (1/10) isolates of K. pneumoniae were sensitive to compound 4. Concerning the antifungal effects of compounds 3, 4, 5, 13, 14, 15 the results revealed that, all C. albicans and C. glabrata isolate were resist these compounds
Authors and Affiliations
Nadhir Najim abdullah Jafar , Hussein Oleiwi Muttaleb Al-Dahmoshi , Najim Abod Al-Masoudi
Keywords
Related Articles
- EP ID EP88180
- DOI -
- Views 136
- Downloads 0
Evaluation of Wound Healing Activity of Methanolic Extract of Tonna dolium (L.1758)
Marine invertebrates offer a rich source of potential drugs with excellent biological activities. The present study was aimed at investigating the wound healing effect of methanolic extract of Tonna dolium (L.1758) using...
In Vitro Evaluation of Antiulcer Activity of A Polyherbal Mixture
The present study was performed to assess the in vitro acid neutralizing capacity and H+ /K+ - ATPase inhibition activity of a chloroform extract of polyherbal mixture. In acid neutralizing capacity (ANC), the extract si...
Antibacterial and phytochemical analysis of Banana fruit peel
The in vitro antibacterial activity of ethanolic and aqueous extract of banana (Musa sapientum) peels was investigated on both gram-positive and gram-negative bacteria using agar well diffusion technique . The et...
[b] Interaction Between Cibacron Blue F3GA and Luteinizing Hormone: A Chromatographic Investigation[/b]
Chemical constituents and pharmacological activities of Gossypium herbaceum and Gossypium hirsutum - A review
The phytochemical investigations of Gossypium herbaceum showed that it contained carbohydrates, flavonoids, tannins, steroids, terpenoids, saponins, resins, phenols and proteins, while, Gossypium hirsutum contained alkal...