Synthesis and biological activity of new derivatives of 6-chloro-5-((4-chlorophenyl) diazenyl) pyrimidine-2, 4-diamine and 4-chloro-6-methoxy-N, N-dimethylpyrimidin-2-amine
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 1
Abstract
6-chloro-5-((4-chlorophenyl) diazenyl) pyrimidine-2, 4-diamine and 4-chloro-6-methoxy-N,N-dimethylpyrimidin-2-amine has been used as precursors for the synthesis of new pyrimidine derivatives, employing Suzuki cross-coupling reaction. Thus, treatment of pyrimidine derivative with various arylboronic acids in the presence of palladium tetraacetate, PhP3 and Na2CO3 in refluxing n-propanol afforded the target compounds. The synthesis was supported by spectroanalytical techniques. The synthesized compounds have been screened for their inhibitory activity against some microbial, the results were showed that among gram positive isolates only (1/10) isolates of S. aureus and (3/10) isolates of S. saprophyticaus were sensitive for compound 13, while (1/10) isolates of S. aureus and (1/10) isolates of S.saprophyticaus were sensitive for compound 4. All isolates of S. pyogenes were resisting to all compounds, among gram negative bacterial isolates only (2/10) isolates of E. coli and (1/10) isolates of K. pneumoniae were sensitive to compound 4. Concerning the antifungal effects of compounds 3, 4, 5, 13, 14, 15 the results revealed that, all C. albicans and C. glabrata isolate were resist these compounds
Authors and Affiliations
Nadhir Najim abdullah Jafar , Hussein Oleiwi Muttaleb Al-Dahmoshi , Najim Abod Al-Masoudi
Keywords
Related Articles
- EP ID EP88180
- DOI -
- Views 131
- Downloads 0
Rare presentation of left maxillary sinusitis: A Case Report
The maxillary sinus is most commonly affected sinus. The clinical manifestations of rhinosinusitis are diverse. Complications arise due to spread of infection beyond the bony walls (limits) of sinus. However, the&...
Effectiveness of Resveratrol on Metastasis: A Review
Resveratrol’s effects on different cancers have been studied extensively over the past 15 years. Researchers have noted the compound’s potential ability to mitigate cell proliferation and metastasis and promote a...
Chromogenic Spectrophotometric Estimation Of Deflazacort In Bulk & Its Formulation Using 2, 2 Bi Pyridyl Reagent
Simple, precise, economic, less time consuming visible spectroscopic method for Deflazacort was developed by using 2, 2- Bipyridyl and Ferric Chloride. The absorption maximum of the chromogen was found to be 540 nm. The...
Study on Utilization Pattern of Pulmonary Inhalers in Inpatient, Bhagwan Mahaveer Jain Hospital, Bangalore, India
Objective: To study on utilization pattern of pulmonary inhalers in inpatient, Bhagwan Mahaveer Jain Hospital, Bangalore, India. Methods: The proper inhalation technique was assed using the questionnaires there were 11 s...
Brief Communication Thombotic Trombocytopenic Purpura: Allergic Reaction to Plasma Proteins During Therapeutic Apheresis
Thrombotic Thrombocytopenic Purpura (TTP) is a raredisordercharacterized by microangiopathichemolysis with thrombosis. The golds tandard of treatment is the rapeutic plasma exchangewhichreplenishesthedep...