Synthesis and biological activity of new derivatives of 6-chloro-5-((4-chlorophenyl) diazenyl) pyrimidine-2, 4-diamine and 4-chloro-6-methoxy-N, N-dimethylpyrimidin-2-amine
Journal Title: IOSR Journal of Pharmacy (IOSRPHR) - Year 2014, Vol 4, Issue 1
Abstract
6-chloro-5-((4-chlorophenyl) diazenyl) pyrimidine-2, 4-diamine and 4-chloro-6-methoxy-N,N-dimethylpyrimidin-2-amine has been used as precursors for the synthesis of new pyrimidine derivatives, employing Suzuki cross-coupling reaction. Thus, treatment of pyrimidine derivative with various arylboronic acids in the presence of palladium tetraacetate, PhP3 and Na2CO3 in refluxing n-propanol afforded the target compounds. The synthesis was supported by spectroanalytical techniques. The synthesized compounds have been screened for their inhibitory activity against some microbial, the results were showed that among gram positive isolates only (1/10) isolates of S. aureus and (3/10) isolates of S. saprophyticaus were sensitive for compound 13, while (1/10) isolates of S. aureus and (1/10) isolates of S.saprophyticaus were sensitive for compound 4. All isolates of S. pyogenes were resisting to all compounds, among gram negative bacterial isolates only (2/10) isolates of E. coli and (1/10) isolates of K. pneumoniae were sensitive to compound 4. Concerning the antifungal effects of compounds 3, 4, 5, 13, 14, 15 the results revealed that, all C. albicans and C. glabrata isolate were resist these compounds
Authors and Affiliations
Nadhir Najim abdullah Jafar , Hussein Oleiwi Muttaleb Al-Dahmoshi , Najim Abod Al-Masoudi
Keywords
Related Articles
- EP ID EP88180
- DOI -
- Views 116
- Downloads 0
Pharmacological and therapeutic activities of Hedera helix- A review
The phytochemical analysis of Hedera helix revealed that the plant contained unsaturated sterols, oils, tannins, phenolic compounds, terpenoids, glycosides, alkaloids, flavonoids, carbohydrates, reducing sugars, saponins...
Auto-activated Thrombin Expression from Pichia pastorisSMD1168 Optimized by Plackett-Burman Design and Response Surface Methodology
Abstract: Recombinant thrombin (rThrombin) has been used topically as one component of fibrin sealant as the tissue adhesive. Recombinant prethrombin-2 is used as the precursor to generate rThrombin which is then activat...
Complete NMR Assignment of MogrosidesII A2, II E andIII A1Isolated from Luo Han Guo
MR analysis allowed complete assignments of three known mogrol glycosides, Mogroside IIA2 (1), II E (2)and IIIA1 (3), isolated from the extracts of Luo Han Guo. Herein, complete 1H and 13C NMR assignmentsof all t...
Duration-Dependant Effect of Exposure to Rubber Dust Particles on Lung Functional Status among Rubber Factory Workers
: Rubber dust particles affect the respiratory system by directly entering into the respiratory tract while breathing. We analysed the effect and the impact of duration of exposure to these dust particles on the...
Detection of Polycystic Ovary Syndrome and Its Treatment with Pergularia daemia in Rat Models
Polycystic Ovary Syndrome (PCOS) is a heterogeneous, multifaceted disorder which affects mostly the women in the reproductive stage with unclear etiologies. This syndrome is associated with clinical, endocrinolo...