Synthesis and Biological Evaluation of Chalcones as Potential Anti Fungal Agents
Journal Title: International Journal of Engineering and Science Invention - Year 2018, Vol 7, Issue 8
Abstract
AseriesofchalconesweresynthesizedandelucidatedstructurallybyIRand1HNMRspectroscopies.The syntheticcompounds were then screened for antifungal activity using cup plate method against three fungal strains Aspergillus niger, Candida albicans, and Micro sporumgypseum. Among them M. gypseumwas found to be more sensitive to the two chalcones 2′- Hydroxy-4-chlorochalcone and 2′-Hydroxy-4- nitrochalcone were more effective than the clinical candidate ketoconazol fromamongthesevencompoundsscreenedandthusmaybeapotentialcandidatetotreatdermatomycoses.
Authors and Affiliations
Dr. Raksha Gupta
Keywords
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