Synthesis and Biological Evaluation of Some New 1,2,3-Triazole Derivatives As Anti-microbial Agents
Journal Title: JOURNAL OF ADVANCES IN CHEMISTRY - Year 2015, Vol 11, Issue 2
Abstract
A series of 1,2,3-triazole derivatives bearing different chemical entities were prepared starting from 2-(4-phenyl-1H-1,2,3-triazol-1-yl)acetohydrazide, compound 2. The purity of all new compounds was checked by TLC and elucidation of their structures was confirmed by IR, 1H and 13C NMR along with High Resolution Mass Spectrometry (HRMS). All the target compounds were evaluated for their possible antimicrobial activity. Most of the tested compounds showed moderate to good antibacterial activity against most of the bacterial strains used in comparison with ciprofloxacin as a reference drug. The most active compounds were 4a, 9a, 9b, and 9f. Results of antifungal activity revealed that most of the tested compounds showed a good antifungal activity in comparison to fluconazole as a reference drug. Compounds 4a, 9c, 9d and 9f were the most active ones.
Authors and Affiliations
Bahaa Gamal Mohamed Youssif, Mostafa H. Abdelrahman
Keywords
Related Articles
- EP ID EP652831
- DOI 10.24297/jac.v11i2.2215
- Views 126
- Downloads 0
Study of the Effective Parameters on Selective Catalytic Reduction of NOx by Ammonia over a Vanadia-Titania Catalyst from Exhaust Gases
The removal of nitrogen oxides (NOx) is crucial problem for global environment. In This study, a 3D dynamic simulation model for the application in investigation of the reaction characteristic and the phenomena of transp...
Structural and spectral studies on benzoyl Thiourea based on DFT calculations
The experimental and theoretical vibrational spectra of benzoyl thiourea were investigated. The experimental FT-IR (400–4000 cm−1) and FT-Raman spectra (100–4000 cm−1) of the molecule in the powder form were reco...
Preparation, characterization, antibacterial and antifungal activities of some transition metal complexes with novel Schiff base ligand derived from N-amino rhodanine
The Schiff base ligand (E)-3-(2-methoxy benzylidene amino)-2-thioxothiazolidin-4-one (L), was prepared from N-amino rhodanine and 2-methoxy benzaldehyde . Moreover, Its complexes were synthesized by mixing metal chloride...
Performance of Al-si-glass fiber composite piston in an IC Engine
The piston is one of the major part of the automobile. The piston purpose is to transfer force from expanding gas in the cylinder to the crankshaft. The piston acts as the vital link between the generation of power insid...
Intercalated nanosized MO2 (M: Sn, Ce) layers between CNTs and Pt or PtSn nanoparticles catalysts
Direct ethanol fuel cells (DEFCs) is receiving enormous attention as alternative electrical energy conversion systems. This paper gives an outline on some recent advances achieved in our laboratory regarding the developm...