SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME NOVEL HETEROCYCLIC MANNICH BASES
Journal Title: International Journal of Research in AYUSH and Pharmaceutical Sciences - Year 2018, Vol 2, Issue 5
Abstract
Various novel heterocyclic mannich bases were prepared by using Mannich reaction. Acetanilide was treated with substituted benzaldehyde and morpholine / methyl amine to give corresponding titled compounds in good yields. The synthesized compounds were characterized by physical properties and spectral studies (IR, 1H-NMR) and tested for antimicrobial activity against Escherichia coli, Bacillus subtilis by using cup plate method with reference to the standard Streptomycin. All the titled compounds show good antimicrobial activity.
Authors and Affiliations
Satya Sree B, A. Lakshmana Rao
Keywords
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