Synthesis and Characterization of Chlorophenylthiazolocoumarinyl Hydrazides as Promising Antimicrobial and Anti-Inflammatory Agents
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 7
Abstract
Recently the reports of resistance to antibacterial drugs have drastically increased. In the search of novel antimicrobial agents, green facile synthesis of substituted phenyl-thiazolocoumarinyl hydrazides was designed and achieved by one-pot reaction of substituted 4-formylcoumarin, thiosemicarbazide, and various phenacyl bromides. The substituted phenyl-thiazolocoumarinyl hydrazides were evaluated preliminarily for their antimicrobial and anti-inflammatory activities. The title compounds have shown excellent in vitro antibacterial activity against the S. aureus and E. coli bacterial strains with the value of low MIC ranges from 0.4 to 6.25µg/mL. In vitro antifungal activity of compounds against fungal strains A. niger and A. flavus was found to be excellent as compared with the standard fluconazole with the MIC in the range of 0.4 to 3.12 µg/mL. Substituted phenyl-thiazolocoumarinyl hydrazides have shown potent anti-inflammatory activity against both MMP-2 and MMP-9 by gelatinase zymography compared with the standard drug as tetracycline. Docking study was performed for compounds with S. aureus DNA gyrase.
Authors and Affiliations
Farzanabi Shaikh, Samundeeswari S, Rashmi Kulkarni, Nirmala S. Naik, Jyoti M. Madar, Shrinivas D. Joshi, Vinay Sunagar, Lokesh Shastri
Keywords
Related Articles
- EP ID EP414335
- DOI 10.9790/5736-1107020939.
- Views 138
- Downloads 0
Microstructural Tissue Assessment, Sex Hormones and Biochemical Investigations Following Acute Administration of Piper GuineenseSchumach&Thonn. on Female RattusNovergicus.
The effect of graded doses (50, 100 and 150mg/kg body weight) of crude ethanol extract of the dry seeds of Piper guineenseSchumach&Thonn was investigated on the ovary, liver, hormonal and some biochemical parameters of f...
Study of Morphometry to Debit Drainage Basin (DAS) Air Dingin Padang City
Drainage Basin Air Dingin is which located in Padang city, part of pate upstream of there are areal protected forest. But the forest used by resident as areal plantation, mining, and activity of illegal logging. This mat...
Effect of Pyridine on the Corrosion Behavior of Electrodeposited Ni-Co Alloy Thin Films and Their Structural and Morphological Analysis
Ni-Co thin films have been grown on Stainless steel substrate by galvanostatic electrodeposition from Sulphate baths containing Pyridine as Organic inhibitor. A comparative study of corrosion parameters were done in thre...
Polymer Structures of N-[{4-(N’-Benzenesulphonicacid) AminoCarbonyl} Phenyl] Maleimide: Synthesis, Thermal and Microbial Studies
Imido-functional group contenting N-[{4-(N’-benzenesulphonicacid) amino-carbonyl} phenyl] maleimide was prepared by reacting species of maleic anhydride, 4-amino benzoic acid and 4-amino sulphanilic acid via chlorination...
Preparation of poly (N-imidazolylmaleamic acid) /nanomaterial coating films on stainless steel by electrochemical polymerization to study the anticorrosion and antibacterial action
Poly (N-Imidazolylmaleamic acid) PIM was synthesized from monomer (N-Imidazolylmaleamic acid) NIMin aqueous solution using electrochemical oxidation procedures. The polymer film was formed on Stainless steel electrodes (...