Synthesis and characterization of coumarin-isoxazole conjugate as potent antibacterial and anti-inflammatory agents
Journal Title: IOSR Journal of Applied Chemistry (IOSR-JAC) - Year 2018, Vol 11, Issue 12
Abstract
A series of novel coumarin isoxazole (3a-3f) and (5a-5f) have been synthesized in good yield starting from 4-formylcoumarins. These newly synthesized coumarin-isoxazole conjugates are mimic structure of valdicoxib which is an anti-inflammatory agent. All the synthesized compounds were screened for their antibacterial and anti-inflammatory activity. The antibacterial activity results exhibited high selectivity against gram positive bacterial strains than gram negative bacterial strains. Interestingly, phenylsulphonamide substituted molecules 5a-5f are more promising against bacterial strains. Further, the anti-inflammatory study showed inhibition of matrix metalloprotiens (MMPs). Particularly, compounds are quite promising with significant inhibition properties against MMP-2 and MMP-9. All the compounds have been characterized by IR, 1HNMR, 13C NMR and mass spectral data.
Authors and Affiliations
Alpana Saxena, Samundeeswari S, Ravindra Chougale, Lokesh Shastri, Shrinivas D. Joshi, Vinay Sunagar
Keywords
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