SYNTHESIS AND CHARACTERIZATION OF RELATED IMPURITIES OF ELETRIPTAN HYDROBROMIDE, AN ANTIMIGRAINE AGENT
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 10
Abstract
Eletriptan hydrobromide is a known orally active antimigraine agent. Four related substances (Impurities) were observed during laboratory process development and pilot scale preparation of Eletriptan. They are desbromo eletriptan, dimer impurity of eletriptan, dehydro analogue and novel intermediate of eletriptan. The present work describes the detection, origin, synthesis, characterization and control of these related substances, thereby providing a commercial method to synthesize substantially pure eletriptan hydrobromide.
Authors and Affiliations
Sudarshan rao, Nageswara rao, chavan Bhausaheb , Radhakrishna singamsetty, A. Jayashree
Keywords
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