Synthesis and cytotoxic activity of G3 PAMAM-NH(2) dendrimer-modified digoxin and proscillaridin A conjugates in breast cancer cells.
Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 2
Abstract
The objective of this study was to determine the cytotoxicity, antiproliferative activity, and apoptosis induction activity of two modified glycosides - digoxin and proscillaridin A - conjugated to a generation 3 polyamidoamine dendrimer (G3 PAMAM-NH(2)) in human breast cancer cells. The results suggest that conjugation with the G3 PAMAM-NH(2) dendrimer enhances the cytotoxicity of modified digoxin and proscillaridin Aboth in MCF-7 and in MDA-MB-231 breast cancer cells. Additionally, the conjugate-induced apoptosis was significantly greater than apoptosis evoked by free modified digoxin and proscillaridin A.
Authors and Affiliations
Katarzyna Winnicka, Krzysztof Bielawski, Anna Bielawska
Keywords
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