SYNTHESIS AND EVALUATION OF ANTIMICROBIAL PROPERTIES OF AZO DYES
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 4
Abstract
Objective: To synthesise and evaluate the antimicrobial potential of azo dyes in the quest of discovering lead molecules.Methods: A number of azo compounds have been synthesized via diazotization of the primary aromatic amine and subsequent coupling with naphthols or other coupling partners. The antimicrobial properties of these azo compounds were determined against six microbes; Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC10231), Mycobacterium smegmatis (clinical strain), Micrococcus luteus (ATCC10240), Pseudomonas aureginosa (ATCC 9027) and the fungi species Candida albicans (ATCC10231) using the Kirby-Bauer Standard disc diffusion method. The minimum inhibition concentrations were also determined for those that exhibited antimicrobial activity.Results: Two of the azo compounds showed antimicrobial potential with p-NAαN in particular exhibiting very good antimicrobial properties. However, Pseudomonas aureginosa (ATCC 9027) was resistant to all the azo compounds.Conclusion: During effective in-vitro control,p-NAαN showed broad spectrum of activity against Staphylococcus aureus, Escherichia coli, Mycobacterium smegmatis, Micrococcus luteu sand the fungi species Candida albicans, with p-ABAα Nexhibiting activity against Candida albicans.
Authors and Affiliations
William Kofie, Cedric Dzidzoramengor, Reimmel K Adosraku
Keywords
Related Articles
- EP ID EP578908
- DOI -
- Views 50
- Downloads 0
POTENTIAL CELL PROLIFERATION INHIBITOR ISOLATED FROM INDONESIAN BROWN ALGAE (PHAEOPHYTA)
Objective: The objective of this study is to determine the toxic activity of n-hexane and ethyl acetate extracts of brown algae as anticancer candidates.Methods: The brown algae were collected from West Java south coast,...
AJUGA IVA TREATMENT INCREASES POST-HEPARIN LIPASE ACTIVITY AND DECREASES SERUM AND VLDL-TRIACYLGLYCEROLS IN RATS FED A CHOLESTEROL-RICH DIET
Objective: Hypercholesterolemia is among the most common health problems treated with traditional remedies. The role of lipoprotein lipase in hypercholesterolemia has been the subject of many reviews. We hypothesized tha...
ISOLATION AND CHARACTERIZATION OF SECONDARY METABOLITES FROM PITHECELLOBIUM DULCE BENTH FRUIT PEEL
Objective: The present study describes the isolation and characterization of valuable secondary metabolites from the fruit peel of Pithecellobium dulce. Methods: Solvent extraction of the plant material using methanol fo...
LAWSONIA ALBA LEAVES INDUCE APOPTOSIS AND CELL CYCLE ARREST IN B16F10 MELANOMA CELLS
Objective: The present study was designed to investigate the anti-melanoma activity of the ethyl acetate fraction of Lawsonia alba lam leaves (ELA) against B16F10 cells.Methods: Cytotoxicity of ELA on B16F10 cells was de...
3-AMINOBENZAMIDE, A POLY (ADP-RIBOSE) POLYMERASE INHIBITOR, RESTORES BIOENERGETICS BUT FAILS TO ALLEVIATE EXCITOTOXICITY AND MOTOR FUNCTIONS IN 3-NITROPROPIONIC ACID INTOXICATED MICE
Objective: The present study was undertaken to investigate the effects of 3-aminobenzamide (3-AB), a poly (ADP-ribose) polymerase 1 (PARP1) inhibitor, on motor functions along with brain excito toxicity and bioenergetics...