SYNTHESIS AND EVALUATION OF NEW 3- SUBSTITUTED-[3, 4-DIHYDROPYRIMIDINONES]-INDOLIN-2-ONES FOR ANALGESIC ACTIVITY 

Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 7

Abstract

45 New 3-substituted [3,4-dihydropyrimidinones]-Indolin-2-ones have been synthesized and tested for Analgesic activity by Eddys Hot plate method on swiss albino mice. Among them compounds AJ43, AJ45, AJ41, AJ16 and AJ17 exhibited higher Analgesic activity. However, the Analgesic activities are lower than standard pentazosin. 

Authors and Affiliations

Ajitha M. , Rajnarayana K. , Sarangapani M.

Keywords

Related Articles

ANALGESIC EFFECT OF THE ETHANOLIC EXTRACT OF MORINGA OLEIFERA LINN. PLANT ON INDUCED ALBINO MICE 

The ethanolic extract of whole part of Moringa oleifera plant in Eddy’s Hot plate method shows markedly increase in the pain threshold of mice. The three different Extract Curative doses of 100 mg/kg, 200 mg/kg and 400 m...

WOUND HEALING ACTIVITY OF ETHANOL EXTRACT OF PSEUDARTHRIA VISCIDA LINN  

The wound healing activity of topically applied ethanol extract of Pseudarthria viscida was evaluated in wistar rat by excision wound model for a period of 12 days. The extract was prepared as ointment form (5 and 10% w/...

FORMULATION AND EVALUATION OF PULSED DRUG DELIVERY OF 5- FLUOROURACIL IN TREATING COLO-RECTAL CANCER 

The proposed work aimed to develop a time dependent programmable pulsatile drug delivery system of 5-Fluorouracil, intended for chronotherapy in colorectal cancer. Various batches of tablets were prepared by direct compr...

BIOREMEDIATION OF PICOLINE BY ADAPTING P. AERUGINOSA ISOLATED FROM INDUSTRIAL EFFLUENT POLLUTED WATER  

Environmental pollution implies any alteration in the surroundings but it is restricted in use especially to mean any deterioration in the physical, chemical, and biological quality of the environment. All types of pollu...

ANTI- MICROBAL EFFICACY OF MEDICINALLY IMPORTANT PLANTS (C. PHLOMIDIS) USED IN FOLKARIC MEDICINES IN ARID ZONE 

The present investigation was undertaken to evaluate in vivo antimicrobial activity of different extracts (Methanol, Benzene and Aqueous) of Clerodendrum phlomidis plants parts. In vivo antimicrobial efficacy of various...

Download PDF file
  • EP ID EP140243
  • DOI -
  • Views 68
  • Downloads 0

How To Cite

Ajitha M. , Rajnarayana K. , Sarangapani M. (2011). SYNTHESIS AND EVALUATION OF NEW 3- SUBSTITUTED-[3, 4-DIHYDROPYRIMIDINONES]-INDOLIN-2-ONES FOR ANALGESIC ACTIVITY . International Research Journal of Pharmacy (IRJP), 2(7), 80-84. https://europub.co.uk/articles/-A-140243