Synthesis and microbial screening of 6-pyridin-4-yl-2, 3-dihydro-1Hpyridazin- 4-one derivatives
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2013, Vol 1, Issue 3
Abstract
6-pyridin-4-yl-2, 3-dihydro-1H-pyridazin-4-one derivatives were synthesized by a simple method. The isonicotinic acid hydrazide was made to react with acetaldehyde and acetone. This results into the formation of the respective hydrazones. These hydrazones formed were cyclized to the pyridazine derivatives. All synthesized compounds were subjected to antimicrobial activity.
Authors and Affiliations
Athar Javed| Govt. College of Pharmacy, Rohru, Shimla, H. P. India, M. S. Bhatia| Bharti Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India, Mayuresh Shinde| Bharti Vidyapeeth College of Pharmacy, Kolhapur, Maharashtra, India, Vinod Singh| Gurukul Kangri University, Uttarakhand, India
Keywords
Related Articles
- EP ID EP13637
- DOI -
- Views 311
- Downloads 20
Small-scale screening program for the identification of cytotoxic Oxazolo[5,4-d]pyrimidine derivatives based on Whole Cell Viability Assay
For over last couple of decades, there has been a robust activity aimed towards the discovery of novel anti-cancer therapeutics. An approach to identify starting points for new drug candidates is high throughput screen...
In vitro antimicrobial activity of leaves and bark extracts of Ficus religiosa (Linn.)
In the present study we investigated antimicrobial activity of diethyl ether and methanol extractions of bark and leaves of Ficus religiosa plant against three bacteria (E.coli, Staphylococcus aureus & Pseudomonas auri...
Dehydration for Better Quality Value Added Product of Bitter Gourd (Momordica charantia L.)
An experiment was carried out to evaluate the dehydration and rehydration characteristics of bitter gourd (Momordica charantia L.) fruits. The slices of bitter gourd were blanched in boiling water and steam for 1, 2 and...
Life style Factors Influencing BMI of Females In Ha’il Region
Background: Published health promoting or health risk behaviors data in a young population is sparse for Saudi Arabia. Identifying health risk factors early in life and promoting primary prevention interventions among...
Fabrication and Optimization of Novel Lornoxicam Matrix Tablets Using 3-Factor 3- Level Box-Behnken Statistical Design: Invitro and Invivo Evaluation
In the present study efforts have been made to prepare sustained release matrix tablets of Lornoxicam. Matrix tablets were prepared by direct compression method by using Hydroxypropyl methyl cellulose K15 (HPMC- K15),...