Synthesis and Pharmacological Activity of Metal Complexes having Hydrazinobenzimidazole Based Ligands
Journal Title: Journal of Biological and chemical Chronicles - Year 2018, Vol 4, Issue 2
Abstract
The complexes of N1-{(1E)-1H–benzimidazol–2–yl) ethylidene 2–hydrazinobenzimidazole} (BahbH) with some transition metal ions of composition, M(BahbH)2Cl2 (M=MnII, CoII, NiII), [M (BahbH)X2] (M=CuII and X=Cl– or Br–, when M=ZnII, CdII, X=Cl or I) Cu (BahbH)I, Ag (BahbH) NO3, [M(BahbH)2] SO4.nH2O (M=MnII, CoII or NiII and n=1 or 2) have been prepared and characterized by elemental analysis, and studies of IR, UV, Magnetic susceptibility values and electrical conductance measurements at room temperature. The magnetic and spectral properties of MnII, CoII and NiII complexes are consistent with octahedral structure. The complexes [M(BahbH)X2] have five coordinated pseudo trigonal bipyramidal structure. The ligand and its complexes with CuII, MnII, FeII, ZnII, CdII and AgI were screened for their antifungal and antibacterial activities. The complexes showed positive antifungal and two strains of Proteins mirabilis and Bacillus subtilis.
Authors and Affiliations
Anand Mohan Jha, Madhu Bala, K. K. Jha, L. K. Mishra
Keywords
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