Synthesis and physico-chemical properties of some derivatives of 7-((3-thio-4R-4H-1,2,4-triazole-5-yl)methyl)theophylline
Journal Title: Фармацевтичний журнал - Year 2014, Vol 6, Issue 6
Abstract
Biologically active agents based on naturally occurring xanthines are used widely in medicine. Compounds containing in their structure the 1,2,4-triazole nucleus are slightly toxic or non-toxic substances with high biological activity, have antimicrobial, neurotropic, antioxidant, anti-inflammatory, antifungal, hypolipidemic activity. The synthesis of compounds which contain in their structure a fragment of theophylline and 1,2,4-triazole nucleus is important. The aim of the work is new derivatives of 7-((3-thio-4-R-4H-1,2,4-triazole-5-yl)methyl)theophylline synthesis and research of their physical and chemical properties. Sodium salt of theophylline was used as the initial substance to obtain a new series of this compounds. The 7-((3-thio-4-R-4H-1,2,4-triazole-5-yl)methyl)-theophyllines were obtained through a series of consecutive stages. The obtained compounds were useful initial semi-products, which in its structure had CH- and SH-acidic centers. A number of not described in the literature substances that represents a certain interest in terms of biologically active compounds investigation were synthesized. The structure of the synthesized compounds was confirmed by elemental analysis methods, IR-spectroscopy, chromato-mass and mass-spectrometry. The protonation of 7-((3-thio-4-R-4H-1,2,4-triazole-5-yl)methyl)theophylline using quantum-chemical calculations was determined. The reactivity was determined on the basis of quantum-chemical calculations ability of 7-((3-thio-4-R-4H-1,2,4-triazole-5-yl)methyl)theophylline. The chromatography-mass and mass-spectrometric research or the synthesized compounds was conducted.
Authors and Affiliations
A. S. Gotsulya, О. І. Panasenko, Ye. G. Knysh, A. O. Pryimenko, B. О. Varynskyi
Keywords
Related Articles
- EP ID EP590465
- DOI -
- Views 72
- Downloads 0
Development of techniques to identify and determine the active ingredient in dental gel composition
The technique of the qualitative and quantitative determination of active substances – decamethoxine and lidocaine hydrochloride in a new combination drug for preventing and treating inflammatory diseases of the oral cav...
Advantages and perspectives of using medicines in the form of auto injectors and prefilled syringes
Today, there is a need to introduce medical devices into everyday medical practice with the goal to self-administer injectional drugs. The speed and safety of auto-injectors / pre-filled syringe pens use (AI/PFS) is the...
Investigation of quality indicators and studying the stability of “Propolis-AK” gel for the treatment of acne disease
In modern conditions, the incidence of acne, which is a polymorphic multifactorial disease of the sebaceous glands of the skin, has a tendency to significant growth. Localization of lesions on the face in almost all pati...
Development and validation of the methods of phenytoin determination in urine by the method of gas–liquid chromatography
Development of the methods of strong medicines determination in human biological liquids for application in forensic and clinical toxicology is one of actual problems of pharmaceutical science, but validation of the anal...
Inhibition of 4-aminopyridine-induced seizures in mice by a novel 3-substituted 1,4-benzodiazepine
Some of highly effective antiepileptic substances share the polymodal pharmacological action which determines the possibility of their use for treatment of pathogenetically similar diseases. Inhibitory mediator systems i...