Synthesis and physico-chemical properties of some derivatives of 7-((3-thio-4R-4H-1,2,4-triazole-5-yl)methyl)theophylline
Journal Title: Фармацевтичний журнал - Year 2014, Vol 6, Issue 6
Abstract
Biologically active agents based on naturally occurring xanthines are used widely in medicine. Compounds containing in their structure the 1,2,4-triazole nucleus are slightly toxic or non-toxic substances with high biological activity, have antimicrobial, neurotropic, antioxidant, anti-inflammatory, antifungal, hypolipidemic activity. The synthesis of compounds which contain in their structure a fragment of theophylline and 1,2,4-triazole nucleus is important. The aim of the work is new derivatives of 7-((3-thio-4-R-4H-1,2,4-triazole-5-yl)methyl)theophylline synthesis and research of their physical and chemical properties. Sodium salt of theophylline was used as the initial substance to obtain a new series of this compounds. The 7-((3-thio-4-R-4H-1,2,4-triazole-5-yl)methyl)-theophyllines were obtained through a series of consecutive stages. The obtained compounds were useful initial semi-products, which in its structure had CH- and SH-acidic centers. A number of not described in the literature substances that represents a certain interest in terms of biologically active compounds investigation were synthesized. The structure of the synthesized compounds was confirmed by elemental analysis methods, IR-spectroscopy, chromato-mass and mass-spectrometry. The protonation of 7-((3-thio-4-R-4H-1,2,4-triazole-5-yl)methyl)theophylline using quantum-chemical calculations was determined. The reactivity was determined on the basis of quantum-chemical calculations ability of 7-((3-thio-4-R-4H-1,2,4-triazole-5-yl)methyl)theophylline. The chromatography-mass and mass-spectrometric research or the synthesized compounds was conducted.
Authors and Affiliations
A. S. Gotsulya, О. І. Panasenko, Ye. G. Knysh, A. O. Pryimenko, B. О. Varynskyi
Keywords
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