Synthesis and screening of new 2-(2-oxoindoline-3-ylidene)-n- Phenyl hydrazine carbothioamides
Journal Title: International Journal of Pharmacy and Analytical Research - Year 2014, Vol 3, Issue 1
Abstract
The purpose of this work to prepare or to synthesize the little compound, 2-(2-oxoindoline-3-ylidene)-N-phenyl hydrazine carbothioamide derivatives by adopting appropriate synthetic routes. Then Purification and characterization of all the new compounds including those of intermediates by recrystallization from appropriate solvents or by chromatographic techniques. And Characterization of the newly synthesized compounds by physical and spectral methods (IR, 1HNMR & MASS). Finally evaluation of the new compounds for antimicrobial activities by standard methods available in the literature. It is evident from literature that the presence of the indole nucleus found to have various pharmacological activities like antimicrobial, anti-convulsant, MAO inhibitory, anticancer and psychotropic activities. The very fact that one of indole derivatives (isatins) is potential synthon, for building synthetically a variety of chemical systems known for their broader and pharmacological applications. In view of pharmacological significance of indole derivatives is planned to synthesize some new indole derivatives containing thiosemicarbazides.
Authors and Affiliations
R Asha
Keywords
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