SYNTHESIS AND SPECTRAL CHARACTERIZATION OF BIS (SUB-PYRROLIDINYL) DIONES
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 6
Abstract
The present work describes the synthesis of new pyrrolidines and chalcone derivatives. Synthesis of chalcones (10-17) were acheved by condensation of diacetyl with substituted benzaldehyds in ethanolic sodium hydroxide (50%)(1:2). The later compounds reacted with Schiff bases (1-8) to yield 1,2-bis(2,4,5-tri (4-aryl)pyrrolidin-3-yl)ethane-1,2-dione (20-27). The characterization of some resulting products were confirmed by physical properties, and spectral data UV-Visible, FT-IR, 1H NMR, 13C NMR.
Authors and Affiliations
Abdul-Wahab J. Al-Hamdany
Keywords
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